神经血管偶联与中枢神经系统疾病

Neurovascular coupling and central nervous system diseases

神经血管偶联是局部神经活动与脑血流变化幅度的关联,主要基于神经血管单元层面调节中枢神经系统血流量,是大脑行使功能活动的重要前提。近年来研究表明,神经血管偶联障碍与一些中枢神经系统疾病密切相关,主要包括慢性脑缺血等脑血管疾病以及阿尔茨海默病、帕金森病、路易体痴呆等神经退行性疾病。神经血管偶联功能障碍导致上述疾病的主要机制是脑血管功能障碍或缺失,进而导致神经元缺血损伤,影响其正常功能。该文将就神经血管偶联研究现状及与其相关的中枢神经系统疾病做一综述,以期指导后继研究,为基于神经血管偶联机制研发预防、缓解、治疗与神经血管偶联相关的中枢神经系统疾病提供依据。

Neurovascular coupling is the function of regulating blood flow of the central nervous system at the level of neurovascular units.The central nervous system diseases related to neurovascular coupling mainly include cerebrovascular diseases such as chronic cerebral ischemia and neurodegenerative diseases such as Alzheimer′s disease,Parkinson′s disease and Lewy body dementia.The main mechanism of neurovascular coupling dysfunction leading to the above diseases is cerebrovascular dysfunction or loss,which leads to serious damage to neuronal ischemia and affects its function.Therefore,this paper reviews the research status of neurovascular coupling and its related central nervous system diseases,in order to guide the follow-up research.The purpose of this paper is to provide a basis for the prevention,relief and treatment of central nervous system diseases related to neurovascular coupling through the mechanism of neurovascular coupling.