猪繁殖与呼吸综合征疫苗的发展现状及mRNA疫苗前景

Development Status of Porcine Reproductive and Respiratory Syndrome Vaccines and Prospects of mRNA Vaccines

猪繁殖与呼吸综合征是猪的重要疫病之一,病猪通常双耳发绀呈蓝紫色,又称猪蓝耳病,这是一种已经造成巨大经济损失的重大疫病,其病原体是一种极易变异与重组的病毒——猪繁殖与呼吸综合征病毒。针对其最重要的防控手段是疫苗接种。已经获批上市的灭活疫苗与减毒活疫苗,以及正在探索中的亚单位疫苗、DNA疫苗等新型疫苗尚无法实现根除该病。mRNA疫苗因其突出的安全、有效、高产及便利等特点,极可能实现对猪蓝耳病的完全预防。论文综述了猪繁殖与呼吸综合征的防控现状、mRNA疫苗的研究进展以及mRNA疫苗用于该种疫病的可能性分析,为猪繁殖与呼吸综合征的防控思考了新的方向。

Porcine reproductive and respiratory syndrome(PRRS)is a significant disease in swine,characterized by blue-purple discoloration of both ears in infected pigs,also known as"blue ear disease".This epidemic has caused substantial economic losses,and the PRRS virus is highly prone to variation and recombination.The vaccination is the most important approach to prevent and control the disease,current available vaccines,including inactivated and live attenuated vaccines,as well as newer subunit and DNA vaccines,have not yet achieved the disease eradication.mRNA vaccines,which are notable for their exceptional safety,efficacy,high yield,and convenience,are highly likely to achieve complete prevention and control of blue ear disease.The paper provides an overview of the current status of PRRS prevention and control,the progress of mRNA vaccine research,and the potential of mRNA vaccines to control this disease,offering new directions for PRRS prevention and control.