乳果糖联合莫沙必利治疗功能性消化不良的疗效及对肠道菌群的影响

Efficacy of lactulose combined with mosapride in treating functional dyspepsia and its effect on intestinal flora

目的探讨功能性消化不良(FD)患者应用乳果糖联合莫沙必利治疗的临床疗效及药物对肠道菌群的影响。方法选取2019年1月—2021年12月来院诊治的180例FD患者作为研究对象,随机分为2组,每组90例,对照组口服莫沙必利片,观察组服用莫沙必利片+乳果糖口服液,4周后观察2组患者治疗后临床症状改善率及肠道菌群数量的情况。结果治疗4周后,观察组的总有效率(86.67%)高于对照组(72.22%),P<0.05;观察组的乳杆菌菌群数多于对照组,肠球菌、肠杆菌菌群数少于对照组,P<0.05。结论乳果糖联合莫沙必利用于FD患者临床治疗,总有效率高于单用莫沙必利,患者症状获得有效改善,明显改善FD患者肠道菌群水平。

Objective To explore the clinical efficacy and effect on intestinal flora of lactulose combined with mosapride in patients with functional dyspepsia(FD).Methods A total of 180 FD patients admitted to the hospital in January 2019 and December 2021 were selected as the study subjects and randomly divided into two groups,90 cases in each group.The control group took oxapride orally and the observation group took lactulose oral solution additionally.After 4 weeks,the improvement rate of clinical symptoms and the number of intestinal flora of patients were observed.Results After 4 weeks of treatment,the total effective rate of the observation group(86.67%)was obviously higher than that of the control group(76.67%),P<0.05;the number of Lactobacillus in the observation group was higher than that of the control group,and the numbers of Enterococcus and Enterobacteria were less than that of the control group,P<0.05.Conclusions The total effective rate of lactulose combined with mosalabin for FD patients is higher than that of mossalapride alone.The symptoms are effectively improved,and the intestinal flora level of FD patients is significantly improved.