奥马环素在特殊人群、特殊病理状态患者中应用研究进展

Progress in research on application of omadacycline in special population and patients with special pathological status

奥马环素是一种新型的广谱抗生素,其药动学参数优良、不良反应少,可采用每日单剂量口服或静脉用药。奥马环素对多种病原体有效,如耐甲氧西林金黄色葡萄球菌、耐万古霉素肠球菌、产超广谱β-内酰胺酶革兰阴性菌、非典型病原体等。奥马环素已被批准用于治疗成人的社区获得性细菌性肺炎(community-acquired bacterial pneumonia,CABP)以及急性细菌性皮肤和皮肤结构感染(acute bacterial skin and skin structure infections,ABSSSI)。本研究通过查阅文献资料,重点对近期研究进展中的特殊患者进行奥马环素治疗后的药动学/药效学(pharmacokinetics/pharmacodynamics,PK/PD)特点进行综述,以期为临床用药提供参考。

Omadacycline is a new broad-spectrum antibiotic with excellent pharmacokinetic characteristics and few adverse reactions.It can be used orally or intravenously once daily.Omadacycline is effective against a variety of pathogens,such as methicillin-resistant Staphylococcus aureus(MRSA),vancomycin-resistant Enterococcus(VRE),extended-spectrum beta-lactamase-producing gram-negative bacteria,atypical pathogens,etc.Omadacycline has been approved for the treatment of community-acquired bacterial pneumonia(CABP)and acute bacterial skin and skin structure infections(ABSSSI)in adults.Through literature review,this paper focused on the pharmacokinetics/pharmacodynamics(PK/PD)characteristics of omadacycline in special patients in recent research,in order to provide reference for clinical medication.