运动对软骨细胞衰老作用机制研究进展

Progress in the study of the mechanism of the effect of exercise on chondrocyte senescence

骨关节炎(osteoarthritis,OA)是最常见的关节病变之一,软骨细胞衰老在OA的发生和发展中起重要作用。以往研究发现运动可以缓解软骨细胞衰老,然而其具体机制尚未完全阐明。目前研究将软骨细胞衰老机制分为复制性衰老和过早衰老两类,本文主要通过总结分析运动对端粒长度、DNA损伤、炎症因子、自噬、机体抗氧化能力以及胰岛素样生长因子1和巨噬细胞的影响,以明确运动在抑制软骨细胞衰老中的作用,为临床上治疗OA提供新靶点。

Osteoarthritis(OA)is one of the most common joint pathologies,and chondrocyte senescence plays an important role in the development and progression in OA.Previous studies found that exercise could alleviate chondrocyte senescence,however,the exact mechanisms involved have not been fully elucidated.Current researches classified chondrocyte senescence mechanisms into two categories:replicative senescence and premature senescence.In this review,we focused on the effects of exercise on telomere length,DNA damage,inflammatory factors,autophagy,antioxidant capacity of the body,as well as insulin-like growth factor 1 and macrophages,in order to identify the role of exercise in inhibiting chondrocyte senescence and to provide new targets for the clinical treatment of OA.