替格瑞洛在冠状动脉介入治疗中的应用效果

Application Effect of Ticagrelor in Coronary Artery Intervention Therapy

目的:探讨冠状动脉介入治疗中应用替格瑞洛的效果。方法:选取2020年9月—2022年6月于天水市第一人民医院行冠状动脉介入治疗的78例患者作为研究对象,根据随机数字表法分为两组,各39例。对照组采用氯吡格雷治疗,观察组采用替格瑞洛治疗。比较两组治疗效果。结果:治疗后,两组心肌梗死溶栓(TIMI)血流分级0级、2级占比比较,差异无统计学意义(P>0.05);观察组TIMI血流分级1级占比低于对照组,3级占比高于对照组,差异有统计学意义(P<0.05)。治疗后,两组心肌灌注分级(TMPG)0级、1级占比比较,差异无统计学意义(P>0.05);观察组TMPG2级占比高于对照组,差异有统计学意义(P<0.05)。治疗后,两组白细胞介素-6、C反应蛋白及肿瘤坏死因子-α水平高于治疗前,但观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组心肌酶谱肌酸激酶同工酶、肌钙蛋白、乳酸脱氢酶水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论:替格瑞洛在冠状动脉介入治疗中的应用效果显著,可改善患者术后冠状动脉血流情况,减轻炎性反应,保护心肌,改善冠状动脉功能。

Objective:To investigate the effect of ticagrelor in coronary artery intervention therapy.Methods:A total of 78 patients who underwent coronary artery intervention therapy at the First People´s Hospital of Tianshui from September 2020 to June 2022 were selected as the study subjects.They were divided into two groups using a random number table method,with 39 patients in each group.The control group was treated with clopidogrel,and the observation group was treated with ticagrelor.The treatment effects were compared between two groups.Results:There was no significant difference in the proportion of thrombolysis in myocardial infarction(TIMI)blood flow grading 0 and 2 between the two groups after treatment(P>0.05);the proportion of TIMI blood flow grading 1 in the observation group was lower than that in the control group,and the proportion of TIMI blood flow grading 3 in the observation group was higher than that in the control group,with statistically significant differences(P<0.05).There was no significant difference in the proportion of TIMI myocardial perfusion grade(TMPG)grading 0 and 1 between the two groups after treatment(P>0.05);the proportion of TMPG grade 2 in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of interleukin-6,C-reactive protein and tumor necrosis factor-αin the two groups were higher than those before treatment,but the levels in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of myocardial enzyme spectrum creatine kinase isoenzyme,troponin and lactate dehydrogenase in the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion:The application of ticagrelor in coronary artery intervention therapy has a remarkable effect,which can improve the coronary blood flow after surgery,reduce inflammatory reaction,protect myocardium,and improve coronary artery function.