黑色素瘤缺乏因子2炎症小体在心血管疾病中的研究进展

Absent in Melanoma 2 Inflammasome in Cardiovascular Disease

黑色素瘤缺乏因子2(AIM2)可识别来自病原微生物或宿主本身的双链DNA,使活化的胱天蛋白酶-1剪切前白细胞介素-1β和前白细胞介素-18,通过介导炎症因子白细胞介素-1β和白细胞介素-18的成熟和分泌来引起固有免疫应答。此外,AIM2炎症小体可将消皮素D(GSDMD)转化为GSDMD-N,促进细胞因子和各种细胞质内容物的释放,导致细胞膜破裂,引起细胞焦亡。越来越多研究表明,AIM2炎症小体、白细胞介素-1β和细胞焦亡等参与了动脉粥样硬化、心肌梗死和心力衰竭等心血管疾病的发展过程。根据目前研究,现对AIM2炎症小体在心血管疾病发生过程中可能的作用机制做一综述,以期为心血管疾病的靶向治疗提供新思路。

Absent in melanoma 2(AIM2)recognizes double-stranded DNA from pathogenic microorganisms or the host itself,causing activated caspase-1 to shear pro-interleukin(IL)-1β and pro-IL-18 and mediating the maturation and secretion of the inflammatory factors IL-1β and IL-18 to elicit an intrinsic immune response.In addition,AIM2 inflammasome can convert Gasdermin D(GSDMD)to GSDMD-N,which promotes the release of cytokines and various cytoplasmic contents,causing cell membrane rupture and leading to pyroptosis.An increasing number of studies have shown that the development process of cardiovascular diseases,such as atherosclerosis,myocardial infarction and heart failure,is associated with AIM2 inflammasome,IL-1βand pyroptosis.This paper reviews the possible mechanisms of the role of AIM2 inflammasome in the development of cardiovascular diseases based on the current available studies,with the aim of providing new ideas for the targeted therapy of cardiovascular diseases.