摘要
心力衰竭是多种心血管疾病的终末阶段,是一种复杂的临床综合征。心力衰竭时存在自主神经失衡与免疫调节紊乱,二者存在交互作用,免疫细胞可以表达神经递质,自主神经激活后通过神经递质作用于免疫细胞,可调节细胞炎症因子的释放。神经免疫交互作用参与并维持心力衰竭的发生发展。现总结有关心力衰竭神经免疫交互作用的现有知识及临床应用进展,为进一步研究提供支持性的合理背景。
Heart failure is the end stage of several cardiovascular diseases and is a complex clinical syndrome.In heart failure,there is an imbalance of autonomic nervous system and immune regulation disorder,which interact with each other.Immune cells can express neurotransmitters,and after activation of autonomic nervous system,neurotransmitters act on immune cells to regulate the release of cellular inflammatory factors.Neuroimmune crosstalk participates in and maintain the occurrence and development of heart failure.This review summarizes the existing knowledge and clinical application progress of neuroimmune crosstalk in heart failure,and provides a supportive and rational background for further research.
作者
王清
梁小燕
芦颜美
WANG Qing;LIANG Xiaoyan;LU Yanmei(Department of Pacing and Electrophysiology/Department of Cardiac Electrophysiology and Cardiac Remodeling,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,Xinjiang,China)
出处
《心血管病学进展》
CAS
2023年第11期1001-1004,共4页
Advances in Cardiovascular Diseases
基金
国家自然科学基金(81860081)
新疆维吾尔自治区天山英才-青年拔尖科技人才项目(2022TSYCCX0101)。
