摘要
动脉粥样硬化是一种伴有脂质代谢紊乱的慢性炎症反应。NOD样受体蛋白3(NLRP3)炎症小体作为一种多蛋白组成的炎症复合物,与细胞活性、血管炎症、斑块进展密切相关。氧化三甲胺作为肠道菌群主要代谢产物,能启动NLRP3炎症小体的激活,参与粥样硬化斑块形成和斑块破裂的病理学过程。现就氧化三甲胺与NLRP3炎症小体在动脉粥样硬化中的作用进行综述,旨在为动脉粥样硬化的机制研究和临床防治提供新视角。
Atherosclerosis is a chronic inflammatory response with lipid metabolism disorder.NOD-like receptor protein 3(NLRP3)inflammasome,as a multi-protein inflammatory complex,is closely related to cell activity,vascular inflammatory,and the progression of plaque.Trimethylamine oxide,as a major metabolite of intestinal flora,can initiate the activation of NLRP3 inflammasome and participate in the pathophysiological mechanism of atherosclerotic plaque formation and plaque rupture.The paper reviews the role of NLRP3 inflammasome and trimethylamine oxide in atherosclerosis to provide a new perspective for the mechanism research and clinical prevention and treatment of atherosclerosis.
作者
赵海燕
关秀茹
ZHAO Haiyan;GUAN Xiuru(Department of Laboratory Diagnostics,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang,China)
出处
《心血管病学进展》
CAS
2023年第11期1028-1032,共5页
Advances in Cardiovascular Diseases
基金
国家自然科学基金(81672084)。
