过低LDL-C水平在动脉粥样硬化性心血管疾病中潜在风险循证学证据

Evidence of Potential Risk of Excessively Low Levels of LDL-C in ASCVD

高水平低密度脂蛋白胆固醇(LDL-C)是动脉粥样硬化性心血管疾病(ASCVD)的重要危险因素。有效地降低LDL-C水平对于ASCVD的预防和治疗都有重要意义,但随着LDL-C目标值逐渐降低,与之相关的潜在风险开始浮现,值得关注。现就过低LDL-C水平的相关潜在风险循证学证据进行综述。

High levels of low-density lipoprotein cholesterol(LDL-C)is an important risk factor for atherosclerotic cardiovascular disease(ASCVD).Effective reduction of LDL-C is of great significance for prevention and treatment of ASCVD.However,with the gradual reduction of LDL-C target value,the potential risks begin to emerge and deserve our attention.We reviewed the evidence for the potential risks associated with excessively low levels of LDL-C.