急性缺血性脑卒中患者血管内介入治疗后住院期间发生谵妄的影响因素分析

Influencing factors of delirium during hospitalization after intravascular intervention therapy for acute ischemic stroke

目的 探讨急性缺血性脑卒中患者血管内介入治疗后住院期间发生谵妄的影响因素。方法 收集2021年3月至2023年3月于首都医科大学附属北京潞河医院住院治疗的120例急性缺血性脑卒中患者的临床资料,根据住院期间是否发生谵妄将患者分为谵妄组(n=39)和对照组(n=81)。比较两组患者的临床特征、介入治疗情况,分析急性缺血性脑卒中患者血管内介入治疗后住院期间发生谵妄的相关因素。结果 谵妄组患者的年龄、单身的比例、合并高血压的比例均高于对照组患者,差异均有统计学意义(P﹤0.05)。谵妄组患者发病至开通血管﹥6 h的比例高于对照组患者,差异有统计学意义(P﹤0.05)。多因素分析结果显示,年龄≥65岁、合并高血压、发病至开通责任血管时间﹥6 h、单身状态均是急性缺血性脑卒中患者血管内介入治疗后住院期间发生谵妄的独立危险因素(P﹤0.05)。结论 急性缺血性脑卒中患者血管内介入治疗后住院期间谵妄的发生率较高,年龄、高血压、发病至开通责任血管的时间及单身状态均与之密切相关。

Objective To analyze the influencing factors of delirium during hospitalization after intravascular intervention therapy for acute ischemic stroke.Method Clinical data of 120 patients with acute ischemic stroke admitted to the Beijing Luhe Hospital,Captial Medical University from March 2021 to March 2023 were collected.All patients were divided into delirium group(n=39)and control group(n=81)according to presence of delirium during hospitalization.The clinical characteristics and intervention therapy condition of two groups of patients were compared and the risk factors of delirium during hospitalization after intravascular intervention therapy for acute ischemic stroke were analyzed.Result The age,proportion of singlehood and the proportion of hypertension in delirium group were higher than those in control group,and the differences were statistically significant(P<0.05).The proportion of patients with delirium from onset to vasculature>6 h was higher than that of control group,and the differences was statistically significant(P<0.05).The results of multivariate analysis showed that age≥65 years old,combined hypertension,time from onset to the opening of the responsible vessel>6 h, and singlehood were independent risk factors for delirium during hospitalization after intravascular interventional therapy in patients with acute ischemic stroke (P<0.05). Conclusion The incidence rate of delirium during hospitalization after intravascular intervention therapy for acute ischemic stroke is relatively high, and age, hypertension, time from onset to the opening of the responsible vessel, and singlehood are closely related to the occurrence of delirium.