支架辅助弹簧圈颅内栓塞对颅内破裂动脉瘤患者的影响

Effect of stent-assisted coil intracranial embolization in patients with ruptured intracranial aneurysms

目的探讨支架辅助弹簧圈颅内栓塞对颅内破裂动脉瘤患者的影响。方法选取110例颅内破裂动脉瘤患者为研究对象,根据支架辅助方式将其分为对照组(单纯弹簧圈栓塞术,n=55)和研究组(支架辅助弹簧圈栓塞术,n=55)。比较2组患者手术情况及住院时间、神经功能、血清髓磷脂碱性蛋白(MBP)水平、临床疗效以及脑脊液炎症因子水平。结果术后,2组患者神经生长因子(NGF)和脑源性神经营养因子(BDNF)水平高于术前,且研究组高于对照组,差异有统计学意义(P<0.05)。术后,2组患者血清MBP和脑脊液白细胞介素-4(IL-4)、肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)水平高于术前,但研究组低于对照组,差异有统计学意义(P<0.05)。研究组总有效率为96.36%,高于对照组的83.64%,差异有统计学意义(P<0.05)。结论支架辅助弹簧圈颅内栓塞对颅内破裂动脉瘤患者效果较好,可改善患者神经功能,降低其脑脊液炎症水平和血清MBP水平。

Objective To investigate the effect of stent-assisted coil intracranial embolization in patients with ruptured intracranial aneurysms.Methods A total of 110 patients with ruptured intracranial aneurysm were selected as the study objects.The patients were divided into control group(pure embolization with spring coil,n=55)and study group(stent-assisted embolization with spring coil,n=55)according to the stent assisted method.The operation status,length of hospital stay,nerve function,serum myelin basic protein(MBP)level,clinical efficacy and cerebrospinal fluid inflammatory factor level were compared between the two groups.Results After surgery,the levels of nerve growth factor(NGF)and brain-derived neurotrophic factor(BDNF)in the two groups were significantly higher than those before surgery,and those in the study group were significantly higher than those in the control group(P<0.05).After operation,the levels of serum MBP and cerebrospinal fluid interleukin-4(IL-4),tumor necrosis factor-α(TNF-α)and interleukin-8(IL-8)in two groups were significantly higher than those before operation,and those in the study group were significantly lower than those in the control group(P<0.05).The total effective rate of the study group was 96.36%,which was significantly higher than 83.64%of the control group(P<0.05).Conclusion Stent assisted coil intracranial embolization has a good effect in patients with ruptured intracranial aneurysm,which can improve the nerve function of patients,reduce the level of cerebrospinal fluid inflammation and serum MBP.