神经内分泌肿瘤相关生物指标应用的研究进展

Research progress on the application of neuroendocrine tumor related biological indicators

神经内分泌肿瘤(NENs)起源于神经内分泌细胞,可发生于全身多器官,其生物学行为呈高度异质性,既可为惰性生长,也可为侵袭性生长,甚至早期转移,且不同分级分期NENs的生物学特性和预后均有较大差异。因此,该文针对NENs的流行现状、最新世界卫生组织分类及重要的生物标志物等研究热点进行综述,旨在为NENs的临床规范化诊疗及预后预测提供新进展和新思路。

Neuroendocrine tumors(NENs)originate from neuroendocrine cells and can occur in multiple organs of the body.The biological behavior of NENs is highly heterogeneous,which can be inert growth,invasive growth,and even early metastasis.The biological characteristics and prognosis of NENs in different grades and stages are quite different.Therefore,this article reviewed the epidemic status of NENs,the latest World Health Organization classification and important biomarkers,aiming to provide new progress and new ideas for clinical standardized diagnosis and prognosis prediction of NENs.