25羟维生素D3与2型糖尿病肾病的相关性研究

Correlation Study between 25 Hydroxyvitamin D3 and Type 2 Diabetic Ne⁃phropathy

目的探讨25羟维生素D3水平[25 hydroxyvitamin D3,25(OH)D3]与2型糖尿病肾病之间的关联。方法选取2019年6月—2022年6月深圳市罗湖区人民医院内分泌科收治的120例2型糖尿病肾病患者,依据25(OH)D3水平分为正常组[30 ng/mL≤25(OH)D3≤100 ng/mL](n=31)、不足组[20 ng/mL≤25(OH)D3<30 ng/mL](n=44)、缺乏组[25(OH)D3<20 ng/mL](n=45)。分别对3组患者胱抑素C、糖化血红蛋白、尿微量白蛋白/尿肌酐比值(urinary albumin creatinine ratio,UACR)进行对比分析。结果3组患者胱抑素C水平比较,差异有统计学意义(P<0.05)。3组患者总胆固醇水平比较,差异有统计学意义(P<0.05)。不足组与缺乏组UACR均高于正常组,差异有统计学意义(P<0.05)。相关性结果分析显示25(OH)D3与UACR值呈负相关(r=-0.640,P<0.05),25(OH)D3与胱抑素C呈负相关(r=-0.587,P<0.05)。结论25羟维生素D3缺乏可能与糖尿病肾病的发生、发展有关,胱抑素C可能在一定程度上反映糖尿病肾病的严重程度。

Objective To investigate the association between 25 hydroxyvitamin D3 level[(25(OH)D3]and type 2 dia-betes mellitus nephropathy.Methods 120 type 2 diabetes mellitus nephropathy patients hospitalized in the Depart-ment of Endocrinology,Luohu People's Hospital,Shenzhen from June 2019 to June 2022 were selected and divided into the normal group[30 ng/mL≤25(OH)D3≤100 ng/mL](n=31),the insufficient group[20 ng/mL≤25(OH)D3<30 ng/mL](n=44),and the deficient group[25(OH)D3<20 ng/mL](n=45)based on the 25(OH)D3 level.Comparative analy-ses of cystatin C,glycosylated hemoglobin,and urinary albumin creatinine ratio(UACR)were performed in the three groups,respectively.Results Cystatin C levels in three groups were compared,and the difference was statistically sig-nificant(P<0.05).The difference was statistically significant of total cholesterol level among the three groups(P<0.05).UACR in deficiency group and deficiency group was higher than that in normal group,and the difference was statistically significant(P<0.05).Analysis of correlation results showed that 25(OH)D3 was negatively correlated with UACR values(r=-0.640,P<0.05)and 25(OH)D3 was negatively correlated with cystatin C(r=-0.587,P<0.05).Conclusion 25 hydroxyvitamin D3 deficiency may be related to the occurrence and development of diabetes mellitus nephropathy,and cystatin C may reflect the severity of diabetic nephropathy to some extent.