门冬胰岛素联合地特胰岛素治疗妊娠糖尿病的效果分析

Analysis of the Effect of Insulin Aspart Combined with Insulin Detemir inthe Treatment of Gestational Diabetes Mellitus

目的探讨门冬胰岛素联合地特胰岛素治疗妊娠糖尿病的效果。方法选取2020年1月—2023年5月北京燕化医院收治的70例妊娠糖尿病患者,按照投掷硬币法分为两组,参照组35例和研究组35例,对应的治疗方法分别为门冬胰岛素治疗以及门冬胰岛素+地特胰岛素治疗。对比两组妊娠糖尿病患者的血糖水平(糖化血红蛋白水平、空腹血糖水平以及餐后2 h血糖水平)、血糖达标时间(餐后2 h血糖达标时间、空腹血糖达标时间、同时达标时间)及母婴不良结局。结果治疗前,两组患者各项血糖水平比较,差异无统计学意义(P>0.05);治疗后,研究组患者各项血糖水平低于参照组,差异有统计学意义(P<0.05)。研究组餐后2 h血糖达标时间、空腹血糖达标时间及同时达标时间均短于参照组,差异有统计学意义(P<0.05);与参照组系列展开比较,研究组母婴不良结局总发生率低于参照组,差异有统计学意义(P<0.05)。结论临床对妊娠糖尿病患者给予门冬胰岛素+地特胰岛素治疗,有效降低患者血糖水平,缩短血糖达标时间,改善母婴不良结局。

Objective To investigate the effect of insulin aspart combined with insulin detemir in the treatment of ges-tational diabetes mellitus.Methods 70 patients with gestational diabetes mellitus admitted to Beijing Yanhua Hospital from January 2020 to May 2023 were selected as study subjects and divided into two groups according to the coin toss method.There were 35 cases in the reference group and 35 cases in the study group,treated with insulin aspart and in-sulin aspart+insulin detemir,individually.The blood glucose levels(glycosylated hemoglobin level,fasting blood glu-cose level,and 2-hour postprandial blood glucose level),the time to reach the blood glucose standard(2-hour post-prandial blood glucose standard,fasting blood glucose standard,and the time to reach the standard at the same time)were compared between the two groups of gestational diabetes mellitus,and the adverse maternal and infant outcomes of the two groups were also compared statistically.Results Before treatment,compared with the blood glucose levels between the two groups,and the difference was not statistically significant(P>0.05).After treatment,the levels of the blood glucose of patients in the study group were lower than those of the reference group,and the difference was statis-tically significant(P<0.05).The postprandial 2-hour blood glucose standardization time,fasting blood glucose stan-dardization time,and simultaneous standardization time unfolding of the study group were shorter than those of the ref-erence group,and the difference was statistically significant(P<0.05).The total incidence of adverse maternal and in-fant outcomes of the study group were lower than that of reference group,and the difference was statistically signifi-cant(P<0.05).Conclusion Clinical treatment of gestational diabetes mellitus patients with insulin aspart+insulin de-temir can effectively promote the reduction of blood glucose levels,shortening of the time to achieve blood glucose standards and the improvement of maternal and infant adverse outcomes.