慢性精神分裂症住院患者体质指数与同型半胱氨酸水平、糖脂代谢及临床症状的关系

Relationship between Body Mass Index and Homocysteine Level,Glyco-lipid Metabolism and Clinical Symptoms in Hospitalized Patients with Chronic

目的探讨慢性精神分裂症住院患者体质指数与同型半胱氨酸水平、糖脂代谢及临床症状之间的关系。方法选取2021年12月—2022年12月常熟市第三人民医院的213例慢性精神分裂症患者为研究对象,按照体质指数(body mass index,BMI)分为高BMI组(BMI≥24 kg/m^(2))90例和BMI正常组(BMI 18~<24 kg/m^(2))123例,分别测定患者同型半胱氨酸水平、空腹血糖、三酰甘油、总胆固醇、高密度脂蛋白胆固醇及低密度脂蛋白胆固醇,采用阳性和阴性症状评定量表评定临床症状。比较两组临床资料,分析体质指数与同型半胱氨酸水平、糖脂代谢、阳性和阴性症状评定量表总分及各因子分的相关性。结果高BMI组空腹血糖、三酰甘油、总胆固醇、低密度脂蛋白胆固醇、同型半胱氨酸水平均高于BMI正常组,但高密度脂蛋白胆固醇以及阳性和阴性症状评定量表中的阴性因子分低于BMI正常组,差异有统计学意义(P<0.05)。相关性分析经Bon-ferroni校正显示,BMI与三酰甘油(r=0.364)、低密度脂蛋白胆固醇(r=0.292)、同型半胱氨酸(r=0.237)呈正相关。结论超重和肥胖的慢性精神分裂症住院患者的血清同型半胱氨酸水平及糖脂代谢水平更高,三酰甘油、低密度脂蛋白胆固醇、同型半胱氨酸水平与体质指数呈正相关。

Objective To investigate the relationship between body mass index(BMI),homocysteine level,glycolipid metabolism and clinical symptoms in patients with chronic schizophrenia.Methods A total of 213 patients with chronic schizophrenia in the Changshu Third People's Hospital from December 2021 to December 2022 were selected as the research objects.According to the body mass index(BMI),they were divided into high BMI group(BMI≥24 kg/m^(2))90 cases and normal BMI group(BMI 18~<24 kg/m^(2))123 cases.The levels of homocysteine,fasting plasma glucose,triglyceride,total cholesterol,high density lipoprotein cholesterol and low density lipoprotein cholesterol were mea-sured respectively.The positive and negative symptom rating scale was used to evaluate the clinical symptoms.The clinical data of the two groups were compared,and the correlation between body mass index and homocysteine level,glucose and lipid metabolism,positive and negative symptom rating scale total score and each factor score was ana-lyzed.Results The levels of fasting plasma glucose,triglyceride,total cholesterol,low density lipoprotein cholesterol and homocysteine in the high BMI group were higher than those in the normal BMI group,but the high density lipopro-tein cholesterol and the negative factor scores in the positive and negative symptom rating scale were lower than those in the normal BMI group,and the differences were statistically significant(P<0.05).Bonferroni correction showed that BMI was positively correlated with triglyceride(r=0.364),low density lipoprotein cholesterol(r=0.292)and homocyste-ine(r=0.237).Conclusion The levels of serum homocysteine and glycolipid metabolism were higher in overweight and obese hospitalized patients with chronic schizophrenia,and the levels of triglyceride,low density lipoprotein choles-terol and homocysteine were positively correlated with body mass index.