艾普拉唑联合生长抑素治疗胃溃疡伴出血患者的胃功能改善情况及安全性分析

Improvement of Gastric Function and Safety Analysis of Iprrazole Combined with Ssomatostatin in the Treatment of Patients with Gastric Ulcer Accompanied by Bleeding

目的探究艾普拉唑联合生长抑素治疗胃溃疡伴出血患者的药学动力及安全性分析。方法选取2021年2月—2023年1月江苏省仪征市人民医院收治的胃溃疡伴出血患者80例为研究对象,采用随机抽样法分为两组,每组40例。对照组予以艾普拉唑治疗,观察组在对照组基础上联合使用生长抑素治疗。对比分析两组患者凝血指标、胃肠功能及安全性。结果观察组凝血活酶时间、凝血酶原时间、凝血酶时间均短于对照组,差异有统计学意义(t=2.087、2.896、2.045,P<0.05);观察组纤维蛋白原高于对照组,差异有统计学意义(t=1.126,P<0.05)。观察组胃蛋白酶原Ⅰ、胃蛋白酶原Ⅱ水平均低于对照组,而胃泌素水平高于对照组,差异有统计学意义(t=2.971、3.293、2.329,P<0.05)。观察组不良反应发生率为7.50%,低于对照组的25.00%,差异有统计学意义(χ^(2)=4.501,P<0.05)。结论在胃溃疡伴出血患者的治疗方案中,应用艾普拉唑联合生长抑素能够改善凝血指标,调节胃肠功能,同时增加治疗的安全性。

Objective To explore the pharmacologic dynamics and safety of Ilaprazole combined with Somatostatin in the treatment of patients with gastric ulcer accompanied by bleeding.Methods A total of 80 patients with gastric ulcer accompanied by bleeding admitted to the People's Hospital of Yizheng City,Jiangsu Province from February 2021 to January 2023 were selected and divided into two groups with 40 cases in each group by random sampling.The control group was treated with iprazole,and the observation group was treated with Somatostatin on the basis of the control group.Blood coagulation index,gastrointestinal function and safety of the two groups were compared.Results The thrombin time,prothrombin time and thrombin time in the observation group were shorter than those in the control group,the difference was statistically significant(t=2.087,2.896,2.045,P<0.05).The fibrinogen in observation group was higher than that in control group,and the difference was statistically significant(t=1.126,P<0.05).The levels of pepsinogenⅠand pepsinogenⅡin the observation group were lower than those in the control group,while the levels of gastrin in the control group were higher,the difference was statistically significant(t=2.971,3.293,2.329,P<0.05).The incidence of adverse reactions in the observation group was 7.50%,lower than that in the control group(25.00%),and the difference was statistically significant(χ^(2)=4.501,P<0.05).Conclusion In the treatment of gastric ulcer pa-tients with bleeding,Ilaprazole combined with Somatostatin can improve coagulation index,regulate gastrointestinal function,and increase the safety of treatment.