液体硅橡胶功能改性及其医学应用研究进展

Biofunctionalization of Liquid Silicone Rubber for Medical Applications

液体硅橡胶具有良好的化学稳定性和生物相容性,广泛应用于医疗及医疗器械领域,然而,在实际应用中存在机械支撑强度不足、稳定性不足以及易引发感染等缺陷。因此,提升液体硅橡胶的机械强度、抗菌性、化学稳定性和生物活性是首先要解决的问题。研究发现,将各种纳米填料添加到液体硅橡胶基质中,不仅可以提高材料的力学性能,还可以将其电学和抗菌性能提高到一个较好的水平。简要总结了液体硅橡胶的分类、构建及性能改进方式,重点阐述了液体硅橡胶在医学领域应用过程中的研究现状及目前所面临的瓶颈问题。液体硅橡胶生物医学功能改性研究有望提升纳米材料在液体硅橡胶中的分散性并改善其抗菌性、稳定性和导电性,提升液体硅橡胶的应用价值并拓展其应用场景。

Liquid silicone rubber has good chemical stability and biocompatibility and is widely used in medical and medical equipment fields.However,in practical applications,there are several shortcomings,such as insufficient mechanical support strength,insufficient stability,and easy to cause infection.Therefore,improving the mechanical strength,antibacterial properties,chemical stability and biological activity of liquid silicone rubber is the primary problem to be solved.It was found that adding various nanofillers to the liquid silicone rubber matrix can not only improve the mechanical properties,but also improve the electrical and antibacterial properties to a better level.This paper briefly summarizes the classification,construction and performance improvement methods of liquid silicone rubber,and focuses on the current research status and bottleneck problems in the application of liquid silicone rubber in the medical field.The research progress of biomedical functional modification of liquid silicone is expected to improve the dispersion of nanomaterials in liquid silicone and improve its antibacterial,mechanical and stability,enhance the application value of liquid silicone rubber and expand its application scenarios.