舍曲林联合坦度螺酮治疗青少年抑郁症非自杀性自伤行为的临床观察

Clinical Observation of Sertraline Combined with Tandospirone in the Treatment of Adolescent Depression with Non-suicide Self-injury Behavior

目的:观察和分析青少年抑郁症非自杀性自伤行为(NSSI)患者联合应用舍曲林与坦度螺酮治疗的效果。方法:选取2022年10月—2023年1月于福建省福州神经精神病防治院治疗的72例青少年抑郁症NSSI患者作为研究对象,按照住院顺序编号后以随机数表法将患者分为对照组和观察组,各36例。两组均采用盐酸舍曲林片治疗,观察组加用枸橼酸坦度螺酮胶囊治疗,比较两组临床疗效、负性情绪[汉密尔顿抑郁量表-17项版(HAMD-17)评分、汉密尔顿焦虑量表(HAMA)评分]、冲动行为[冲动量表(BIS-11)]、NSSI行为及不良反应发生情况。结果:观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组HAMD-17评分与HAMA评分比较,差异无统计学意义(P>0.05);治疗后,两组HAMD-17评分与HAMA评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组注意、运动、缺乏计划及总分比较,差异无统计学意义(P>0.05);治疗后,两组注意、运动、缺乏计划及总分低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组NSSI行为发生情况比较,差异无统计学意义(P>0.05);治疗2周、4周后,两组NSSI行为发生次数少于治疗前,且观察组少于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:青少年抑郁症NSSI患者采用舍曲林联合坦度螺酮治疗能显著改善焦虑与抑郁情绪,还能改善冲动行为和NISSI行为,且不会增加不良反应。

Objective:To observe and analyze the effect of Sertraline combined with Tandospirone in the treatment of adolescent depression patients with non-suicide self-injury behavior(NSSI).Method:A total of 72 adolescent depression patients with NSSI who treated in Fujian Province Fuzhou Neuropsychiatric Hospital from October 2022 to January 2023 were selected as the research objects,the patients were divided into the control group and the observation group by random number table method according to the order of hospitalization,with 36 cases in each group.Both groups were treated with Sertraline Hydrochloride Tablets,and the observation group was treated with Tandospirone Citrate Capsules.The clinical efficacy,negative emotions[Hamilton depression scale-17 item(HAMD-17)score,Hamilton anxiety scale(HAMA)score],impulsive behavior[impulse scale(BIS-11)],NSSI behavior and adverse reactions were compared between two groups.Result:The total effective rate in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).There were no statistically significant differences in HAMD-17 score and HAMA score between two groups before treatment(P>0.05);after treatment,the HAMD-17 score and HAMA score of two groups were lower than those before treatment,which in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant difference in the attention,exercise,lack of planning and total scores between two groups(P>0.05);after treatment,the attention,exercise,lack of planning and total scores of two groups were lowere than those before treatment,and which in the observation group were lower than the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant difference in the frequency of occurrence of NSSI behavior between two groups(P>0.05);after 2 weeks and 4 weeks of treatment,the frequency of occurrence of NSSI behavior in two groups were less than those before treatment,and which in the observation group were less than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion:Sertraline combined with Tandospirone in the treatment of adolescent depression patients with NSSI can significantly improve anxiety and depression,improve impulsive behavior and NISSI behavior,and will not increase adverse reactions.