丙戊酸钠联合左乙拉西坦对癫痫患者脑电图及认知功能的影响

Effects of Sodium Valproate Combined with Levetiracetam on Electroencephalogram and Cognitive Function in Patients with Epilepsy

目的:探讨丙戊酸钠联合左乙拉西坦对癫痫患者脑电图及认知功能的影响。方法:选择2021年3月—2022年2月普宁市人民医院收治的94例癫痫患者,按随机数表法分为两组,各47例。对照组采用丙戊酸钠治疗,观察组在对照组基础上加用左乙拉西坦治疗,两组均持续治疗6个月。比较两组脑电图指标、病情改善情况、认知功能、临床疗效、神经因子及不良反应发生率。结果:治疗前,两组棘波指数、认知功能水平比较,差异无统计学意义(P>0.05);治疗后,观察组棘波指数低于对照组,认知功能评分高于对照组,差异有统计学意义(P<0.05)。治疗前,两组癫痫发作频率、癫痫持续时间比较,差异无统计学意义(P>0.05);治疗后,观察组癫痫发作频率低于对照组,癫痫持续时间短于对照组,差异有统计学意义(P<0.05)。观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组神经因子指标水平比较,差异无统计学意义(P>0.05);治疗后,观察组神经元特异性烯醇化酶(NSE)及髓鞘碱性蛋白(MBP)水平均低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:予以癫痫患者丙戊酸钠联合左乙拉西坦治疗,能够有效改善其脑电图、认知功能及神经功能,加快病情恢复,疗效显著,且不会增加不良反应的发生。

Objective:To investigate the effects of Sodium Valproate combined with Levetiracetam on electroencephalogram and cognitive function in patients with epilepsy.Method:A total of 94 patients with epilepsy admitted to Puning People's Hospital from March 2021 to February 2022 were divided into two groups according to random number table method,with 47 patients in each group.The control group was treated with Sodium Valproate,and the observation group was treated with Levetiracetam on the basis of control group.Both groups were treated for 6 months.Electroencephalogram index,disease improvement,cognitive function,clinical efficacy,neurological factors and incidence of adverse reactions were compared between the two groups.Result:Before treatment,there were no significant differences in spike wave index and cognitive function between the two groups(P>0.05).After treatment,the spike wave index of the observation group was lower than that of the control group,and the cognitive function score was higher than that of the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the frequency and duration of seizures between the two groups(P>0.05).After treatment,the seizure frequency in the observation group was lower than that in the control group,and the seizure duration was shorter than that in the control group,the differences were statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of neural factors between the two groups(P>0.05).After treatment,the levels of neuronal specific enolase(NSE)and myelin basic protein(MBP)in observation group were lower than those in control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Sodium Valproate combined with Levetiracetam can effectively improve the electroencephalogram,cognitive function and neurological function of epilepsy patients,accelerate the recovery of the disease,and the efficacy is significant,and will not increase the occurrence of adverse reactions.