奥美拉唑联合法莫替丁对消化道出血患者的影响

Effect of Omeprazole Combined with Famotidine on Patients with Gastrointestinal Bleeding

目的:探究奥美拉唑联合法莫替丁对消化道出血患者的影响。方法:选取2018年1月—2023年1月无锡市第八人民医院收治的100例消化道出血患者作为研究对象。随机将其分为对照组和观察组,各50例。两组均给予基础治疗,对照组给予奥美拉唑治疗,观察组给予奥美拉唑联合法莫替丁治疗。比较两组治疗前1 d、治疗后3 d脾静脉、门静脉血流量、凝血指标、炎症因子。结果:治疗后3 d,两组脾静脉、门静脉血流量均低于治疗前1 d,观察组脾静脉、门静脉血流量均低于对照组,差异有统计学意义(P<0.05)。治疗后3 d,观察组凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)均短于对照组,纤维蛋白原(FIB)水平高于对照组,差异有统计学意义(P<0.05)。治疗后3 d,两组白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)水平均低于治疗前1 d,观察组IL-6、TNF-α、IL-1β水平均低于对照组,差异有统计学意义(P<0.05)。结论:奥美拉唑联合法莫替丁对消化道出血患者有着显著的影响,能够减少脾静脉、门静脉血流量,改善凝血功能及炎症因子水平。

Objective:To investigate the effect of Omeprazole combined with Famotidine on patients with gastrointestinal bleeding.Method:A total of 100 patients with gastrointestinal bleeding admitted to the Wuxi Eighth People's Hospital from January 2018 to January 2023 were selected as the study objects.They were randomly divided into control group and observation group,50 cases in each group.Both groups were given basic treatment,the control group was given Omeprazole treatment,the observation group was given Omeprazole combined Famotidine treatment.Blood flow of splenic vein,portal vein,coagulation index and inflammatory factors were compared between the two groups at 1 d before treatment and 3 d after treatment.Result:At 3 d after treatment,the blood flow of spleen vein and portal vein in the two groups were lower than those at 1 d before treatment,and the blood flow of spleen vein and portal vein in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).At 3 d after treatment,the prothrombin time(PT)and activated partial thromboplastin time(APTT)in observation group were shorter than those in control group,and the level of fibrinogen(FIB)in observation group was higher than that in control group,the differences were statistically significant(P<0.05).At 3 d after treatment,the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β)in the two groups were lower than those of at 1 d before treatment,and the levels of IL-6,TNF-αand IL-1βin observation group were lower than those in control group,the differences were statistically significant(P<0.05).Conclusion:Omeprazole combined with Famotidine has a significant effect on patients with gastrointestinal bleeding,which can reduce the blood flow of splenic vein and portal vein,improve the coagulation function and the level of inflammatory factors.