不同剂量匹伐他汀治疗老年小动脉闭塞性脑梗死的效果

Effect of Different Doses of Pitavastatin in the Treatment of Small Artery Occlusive Cerebral Infarction in the Elderly

目的:探究不同剂量匹伐他汀治疗老年小动脉闭塞性脑梗死的效果。方法:选取2020年10月—2022年6月随州市曾都医院收治的148例老年小动脉闭塞性脑梗死患者。根据随机数表法将其分为对照组及观察组,各74例。对照组给予2 mg/d匹伐他汀钙片,观察组给予4 mg/d匹伐他汀钙片治疗。比较两组治疗前、治疗6个月后血脂指标、血液流变学指标、炎症因子、神经功能、日常生活能力。结果:治疗6个月后,观察组甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平均低于对照组,高密度脂蛋白胆固醇(HDL-C)水平高于对照组,差异有统计学意义(P<0.05)。治疗6个月后,观察组全血高切黏度、全血低切黏度、血浆黏度、纤维蛋白原水平均低于对照组,差异有统计学意义(P<0.05)。治疗6个月后,观察组超敏C反应蛋白(hs-CRP)、血清淀粉样蛋白A(SAA)水平均低于对照组,差异有统计学意义(P<0.05)。治疗6个月后,观察组美国国立卫生研究院卒中量表(NIHSS)评分低于对照组,Barthel指数(BI)评分高于对照组,差异有统计学意义(P<0.05)。结论:老年小动脉闭塞性脑梗死患者应用4 mg/d匹伐他汀治疗,可降低患者血脂水平、炎症因子,改善血液流变学指标,有效改善患者神经功能,提高患者生活能力。

Objective:To investigate the effect of different doses of Pitavastatin in the treatment of small artery occlusive cerebral infarction in the elderly.Method:A total of 148 elderly patients with small artery occlusive cerebral infarction admitted to Suizhou Zengdu Hospital from October 2020 to June 2022 were selected.They were divided into control group and observation group according to random number table method,74 cases in each group.The control group was given 2 mg/d Pitavastatin Calcium Tablets,and the observation group was given 4 mg/d Pitavastatin Calcium Tablets.Blood lipid indexes,hemorheology indexes,inflammatory factors,nerve function,daily living ability were compared between the two groups before treatment and after 6 months of treatment.Result:After 6 months of treatment,the levels of triglyceride(TG),total cholesterol(TC)and low density lipoprotein cholesterol(LDL-C)in observation group were lower than those in control group,and high density lipoprotein cholesterol(HDL-C)was higher than that in control group,the differences were statistically significant(P<0.05).After 6 months of treatment,whole blood high tangential viscosity,whole blood low tangential viscosity,plasma viscosity and fibrinogen levels in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After 6 months of treatment,the levels of hypersensitive C-reactive protein(hs-CRP)and serum amyloid A(SAA)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After 6 months of treatment,the National Institutes of Health stroke scale(NIHSS)score of the observation group was lower than that of the control group,and the Barthel index(BI)score was higher than that of the control group,and the differences were statistically significant(P<0.05).Conclusion:Treatment with 4 mg/d Pitavastatin for elderly patients with small artery occlusive cerebral infarction can reduce patients'blood lipid levels and inflammatory factors,improve hemorheology indexes,effectively improve patients'neurological function and enhance their life quality.