益生菌联合三联疗法治疗Hp感染患儿的效果及Hp根除效果的影响因素

Effect of Probiotics Combined with Triple Therapy in the Treatment of Children with Hp Infection and Influencing Factors of Hp Eradication Effect

目的:探究益生菌联合三联疗法治疗幽门螺杆菌(Hp)感染患儿的效果及Hp根除效果的影响因素。方法:回顾性分析2019年12月—2022年12月福建医科大学附属福州儿童医院消化内科收治的198例Hp感染患儿的临床资料。根据不同治疗方式将其分为观察组与对照组,各99例。对照组给予三联疗法。观察组在对照组基础上口服益生菌。根据所有患儿治疗后Hp根除效果分为有效组与无效组,并收集两组一般资料。比较对照组及观察组Hp根除效果,治疗前、治疗14 d后症状积分,不良反应。对Hp感染患儿Hp根除效果的影响因素进行单因素及多因素分析。结果:观察组Hp根除率为90.91%,显著高于对照组的70.71%,差异有统计学意义(P<0.05)。治疗14 d后,两组纳差、反酸、腹胀、上腹部疼痛积分均降低,观察组纳差、反酸、腹胀、上腹部疼痛积分均低于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率为9.09%,显著低于对照组的20.20%,差异有统计学意义(P<0.05)。有效组益生菌辅助治疗、依从性好占比均高于无效组,差异有统计学意义(P<0.05)。无益生菌辅助治疗、依从性差均是影响Hp未根除的独立危险因素(P<0.05)。结论:益生菌联合三联疗法根除Hp效果显著,能够有效改善临床症状,减少不良反应。未采取益生菌辅助治疗及依从性差均为影响患儿Hp根除效果的独立危险因素,需引起临床重视。

Objective:To explore the effect of probiotics combined with triple therapy in the treatment of children with Helicobacter pylori(Hp)infection and influencing factors of hp eradication effect.Method:The clinical data of 198 children with Hp infection admitted to the Department of Gastroenterology in Fuzhou Children's Hospital Affiliated to Fujian Medical University from December 2019 to December 2022 were retrospectively analyzed.They were divided into observation group and control group according to different treatment method,with 99 cases in each group.The control group was given triple therapy.The observation group was given oral probiotics on the basis of control group.All children were divided into effective group and ineffective group according to the Hp eradication effect after treatment,and the general data of the two groups were collected.The Hp eradication effect,symptom score before and after 14 d of treatment and adverse reactions were compared between the control group and observation group.The influencing factors of eradication effect of Hp in children with Hp infection was analyzed by single factor and multiple factor.Result:The eradication rate of Hp in observation group was 90.91%,which was significantly higher than 70.71%in control group,and the difference was statistically significant(P<0.05).After 14 d of treatment,the scores of poor appetite,acid reflux,abdominal distension and upper abdominal pain in both groups were decreased,and the scores of poor appetite,acid reflux,abdominal distension and upper abdominal pain in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 9.09%,which was significantly lower than 20.20%in the control group,and the difference was statistically significant(P<0.05).The proportions of probiotic-assisted treatment and good compliance in effective group were higher than those in ineffective group,and the difference was statistically significant(P<0.05).Non probiotic-assisted treatment and poor compliance were independent risk factors for Hp not being eradicated(P<0.05).Conclusion:Probiotic combined with triple therapy has a significant effect on the eradication of Hp,which can effectively improve the clinical symptoms and reduce the adverse reactions.Not taking probiotic-assisted treatment and poor compliance are independent risk factors affecting the eradication effect of Hp in children,which should be paid attention to in clinic.