盐酸氨溴索雾化吸入联合哌拉西林钠他唑巴坦钠治疗急性支气管扩张合并肺部感染的效果

Effect of Ambroxol Hydrochloride Nebulization Inhalation Combined with Piperacillin Sodium and Tazobactam Sodium in the Treatment of Acute Bronchiectasis Complicated with Pulmonary Infection

目的:探析盐酸氨溴索雾化吸入联合哌拉西林钠他唑巴坦钠治疗急性支气管扩张合并肺部感染的效果。方法:选取2021年7月—2022年10月漳浦县医院收治的100例急性支气管扩张合并肺部感染患者。根据随机信封法将其分为对照组和研究组,各50例。对照组给予阿奇霉素治疗,研究组在对照组的基础上给予盐酸氨溴索雾化吸入联合哌拉西林钠他唑巴坦钠治疗。比较两组临床疗效,时间指标,治疗前、治疗后3 d肺功能,治疗前后炎症因子,不良反应。结果:研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。研究组咳嗽咳痰减轻时间、胸闷气促消失时间、肺部干湿啰音消失时间均早于对照组,差异有统计学意义(P<0.05)。治疗后3 d,研究组第1秒用力呼气容积(FEV1)、FEV1/用力肺活量(FVC)%、肺总量(TLC)均高于对照组,差异有统计学意义(P<0.05)。治疗后,研究组白细胞介素-4(IL-4)、白细胞介素-10(IL-10)、C反应蛋白(CRP)水平均低于对照组,差异有统计学意义(P<0.05)。研究组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:针对急性支气管扩张合并肺部感染患者,采用盐酸氨溴索雾化吸入联合哌拉西林钠他唑巴坦钠不仅能够改善患者肺功能和炎症因子指标,促进患者康复,还能在提升临床疗效的基础上减少药物副作用。

Objective:To explore the effect of Ambroxol Hydrochloride nebulization inhalation combined with Piperacillin Sodium and Tazobactam Sodium in the treatment of acute bronchiectasis complicated with pulmonary infection.Method:A total of 100 patients with acute bronchiectasis complicated with pulmonary infection admitted to Zhangpu Hospital from July 2021 to October 2022 were selected.According to the random envelope method,they were divided into control group and study group,50 cases in each group.The control group was treated with Azithromycin,and the study group was treated with Ambroxol Hydrochloride nebulization inhalation combined with Piperacillin Sodium and Tazobactam Sodium on the basis of the control group.The clinical efficacy,time index,lung function before and 3 d after treatment,inflammatory factors before and after treatment,and adverse reactions were compared between the two groups.Result:The treatment total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).The reduction time of cough and phlegm,the disappearance time of chest tightness and shortness of breath,and the disappearance time of lung dry and wet rales in the study group were earlier than those in the control group,and the differences were statistically significant(P<0.05).At 3 d after treatment,forced expiratory volume in one second(FEV1),FEV1/forced vital capacity(FVC)%and total lung capacity(TLC)of the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of interleukin-4(IL-4),interleukin-10(IL-10)and C-reactive protein(CRP)in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:For patients with acute bronchiectasis complicated with pulmonary infection,Ambroxol Hydrochloride nebulization inhalation combined with Piperacillin Sodium and Tazobactam Sodium can not only improve lung function and inflammatory factor indexes of patients,promote patients'rehabilitation,but also reduce drug side effects on the basis of improving clinical efficacy.