替罗非班联合介入取栓对急性缺血性脑卒中患者的影响

Effect of Tirofiban Combined with Interventional Thrombectomy on Patients with Acute Ischemic Stroke

目的:探讨替罗非班联合介入取栓对急性缺血性脑卒中(AIS)患者的影响。方法:选取2019年1月—2023年5月南京市高淳人民医院神经内科收治的120例AIS患者。根据随机数表法将其分为对照组和观察组,各60例。对照组给予介入取栓治疗,观察组在对照组基础上给予替罗非班治疗。比较两组治疗前后脑源性神经营养因子(BDNF)水平、凝血功能、神经功能及预后情况。结果:治疗后,两组BDNF水平升高,观察组BDNF水平高于对照组,差异有统计学意义(P<0.05)。治疗后,两组纤维蛋白原(FIB)低于治疗前,活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)均长于治疗前,观察组FIB水平低于对照组,APTT、PT、TT均长于对照组,差异有统计学意义(P<0.05)。出院时,两组美国国立卫生研究院卒中量表(NIHSS)评分低于治疗前,观察组NIHSS评分、改良Rankin量表(mRS)评分均低于对照组,差异有统计学意义(P<0.05)。结论:替罗非班联合介入取栓能够提高BDNF水平,降低高凝的血管状态,从而有效改善患者的预后。

Objective:To investigate the effect of Tirofiban combined with interventional thrombectomy on patients with acute ischemic stroke(AIS).Method:A total of 120 AIS patients admitted to the Department of Neurology of Nanjing Gaochun People's Hospital from January 2019 to May 2023 were selected.They were divided into control group and observation group according to random number table method,with 60 cases in each group.The control group was given interventional thrombectomy treatment,and the observation group was given Tirofiban on the basis of the control group.The level of brain-derived neurotrophic factor(BDNF),coagulation function,nerve function before and after treatment and prognosis condition of the two groups were compared.Result:After treatment,the level of BDNF in the two groups increased,and the level of BDNF in the observation group was higher than that in the control group,the differences were statistically significant(P<0.05).After treatment,fibrinogen(FIB)in both group were lower than those before treatment,activated partial thromboplastin time(APTT),prothrombin time(PT)and thrombin time(TT)in both groups were longer than those before treatment,FIB level in observation group was lower than that in control group,APTT,PT and TT were longer than those in control group,the differences were statistically significant(P<0.05).At discharge,the National Institutes of Health stroke scale(NIHSS)scores of the two groups were lower than those before treatment,and the NIHSS score and modified Rankin scale(mRS)score of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).Conclusion:Tirofiban combined with interventional thrombectomy can improve the level of BDNF,reduce the hypercoagulable vascular state,and effectively improve the prognosis of patients.