重症患者维生素B_(1)水平与脓毒症及乳酸水平相关性研究

Correlation between vitamin B^(1)levels with sepsis and lactate levels in critically ill patients

目的确定重症患者维生素B_(1)缺乏的发生率,比较维生素B_(1)水平在脓毒症患者与非脓毒症患者之间的差异,并探讨维生素B_(1)水平与乳酸水平之间的关系。方法采用回顾性研究方法,将2022年2月—2022年11月收入南京大学医学院附属鼓楼医院重症医学科的危重症患者纳入研究,根据入院诊断将患者分为脓毒症组与非脓毒症组,分析两组间患者维生素B_(1)水平差异,并分析维生素B_(1)水平与乳酸水平相关性。结果脓毒症组患者血清维生素B_(1)水平与非脓毒症组患者比较差异有统计学意义[(1.6±0.3)ng/m L比(2.1±0.2)ng/m L,P=0.009]。对于所有患者,维生素B_(1)水平与乳酸水平无显著相关性,但当乳酸水平≥2 mmol/L即患者处于高乳酸状态时,维生素B_(1)水平与乳酸水平呈显著负相关(r=-0.229,P=0.004)。结论维生素B_(1)缺乏在重症患者中普遍存在,且与患者是否脓毒症密切相关。当患者乳酸水平≥2 mmol/L时,维生素B_(1)水平与乳酸水平显著负相关。

Objective To determine the incidence of vitamin B_(1)deficiency in critically ill patients,to compare vitamin B_(1)levels between septic and non-septic patients,and to explore the relationship between vitamin B_(1)levels and lactate levels.Methods Using a retrospective study method,critically ill patients admitted to the Department of Intensive Care of Nanjing Drum Tower Hospital from February 2022 to November 2022 were included in the study,and the patients were divided into sepsis and non-sepsis groups according to the admission diagnosis,and the differences in the vitamin B_(1)levels of the patients between the two groups were analyzed,as well as the correlation between the vitamin B_(1)levels and the lactic acid levels.Results There was a significant difference in serum vitamin B_(1)levels between the sepsis patients and the non-sepsis patients[(1.6±0.3)ng/mL vs.(2.1±0.2)ng/mL,P=0.009].For all patients,there was no correlation between vitamin B_(1)levels and lactate levels.But when the patient was in a hyperlactate state(lactate level≥2 mmol/L),vitamin B_(1)levels were significantly negatively correlated with lactate levels(r=-0.229,P=0.004).Conclusions Vitamin B_(1)deficiency is prevalent in critically ill patients and is strongly correlated with whether or not the patient is septic.Vitamin B_(1)levels are significantly and negatively correlated with lactate levels when the patient's lactate level is≥2 mmol/L.