摘要
在缺血性脑卒中-再灌注过程中,活性氧异常增多引起的脑组织神经元氧化应激是脑缺血-再灌注损伤的最主要病理机制。快速恢复脑组织血流灌注,同时抑制神经元氧化损伤是治疗缺血性脑卒中的有效途径。目前抗氧化类药物存在生物利用率低、作用方式单一及副作用大等缺点,极大限制了其疗效与临床应用。近年来,纳米药物因其尺寸、形貌可控及表面可修饰性等优势,在生物应用中展现出良好的应用前景,有望突破缺血性脑卒中神经保护类药物开发的瓶颈。重点阐明脑缺血-再灌注损伤的机制,综述抗氧化纳米药物的设计合成及其逆转神经元氧化损伤的作用机制与应用,为防治缺血性脑卒中提供新的思路。
The main pathogenic mechanism of ischemic stroke-reperfusion injury is neuronal oxidative stress induced by aberrant increase in reactive oxygen species during the ischemic stroke-reperfusion process.Restoration of blood flow in cerebral tissue while inhibiting neuronal oxidative damage would be an effective way to treat ischemic stroke.Currently,the efficacy and application of clinical antioxidant drugs are greatly restricted by their low bioavailability,single mode of action,and serious side-effects.In recent years,nanomedicines have shown promising biological applications due to their controllable size and morphology and high surface modification,which are expected to break the bottleneck in the development of neuroprotective drugs for ischemic stroke.This review elucidates the mechanism of cerebral ischemia-reperfusion injury and summarizes the design and synthesis of antioxidant nanomedicines,their mechanism of action and application in reversing oxidative damage in neurons,which will provide a new strategy for the prevention and treatment of ischemic stroke.
作者
刘颖
黄冠宁
贺利贞
陈填烽
LIU Ying;HUANG Guanning;HE Lizhen;CHEN Tianfeng(Department of Neurology and Stroke Center of the First Afiliated Hospital of Jinan University,College of Chemistry and Materials Science,Guangdong Nanochem Innovation Drug Engineering Technology Research Center,Jinan University,Guangzhou 510632,China)
出处
《药学进展》
CAS
2023年第10期779-789,共11页
Progress in Pharmaceutical Sciences
基金
国家自然科学基金国家杰出青年科学基金项目(No.82225025)
国家自然科学基金面上项目(No.32271351,No.21877049,No.32171296)。
关键词
缺血性脑卒中
缺血-再灌注损伤
氧化损伤机制
抗氧化治疗
纳米疗法
ischemic stroke
ischemia-reperfusion injury
oxidative damage mechanism
antioxidant treatment
nanotherapeutics