当归四逆汤相关研究可视化分析

Visual Analysis of Correlative Studies on Danggui Sini Decoction

目的了解当归四逆汤的发展现状和研究热点,以期为相关研究提供借鉴。方法计算机检索CNKI、VIP、万方数据、CBM数据库建库至2022年12月31日收录的当归四逆汤相关研究文献。使用NoteExpress3.6软件对数据进行合并和去重,然后使用CiteSpace5.7.R5软件绘制作者、机构和关键词的知识图谱进行分析。结果纳入文献1970篇,当归四逆汤研究发文量整体呈波动上升趋势;来源期刊发文较多的为《新中医》(74篇),发文较多的作者为赵国平(8篇)、张伯礼(6篇)、马红梅(6篇),发文最多的机构是中国中医科学院广安门医院;共纳入473个关键词,高频关键词有“当归四逆汤加减”“糖尿病周围神经病变”“《伤寒论》”“临床应用”等,形成11个具有代表性的合理聚类及15个突现词。结论当归四逆汤研究热点主要集中在方剂研究、临床应用及实验研究等相关领域,基于网络药理学等方法探索相关通路作用机制是本领域的研究趋势。

Objective To investigate the development status and research hotspot of Danggui Sini decoction,in order to provide reference for related research.Methods The related research literatures of Danggui Sini decoction collected by CNKI,VIP,Wanfang Data and CBM database from the establishment of the database to December 31,2022 were searched by computer.NoteExpress3.6 software was used to merge and deduplicate the data,and then CiteSpace5.7.R5 software was used to draw the knowledge map of authors,institutions and keywords for analysis.Results There were 1970 literatures included,and the number of published papers on Danggui Sini decoction showed an overall trend of fluctuation and increase.The number of published papers in source journals was Journal of New Chinese Medicine(74 articles).The authors who published more articles were ZHAO Guo-ping(8 articles),ZHANG Bo-li(6 articles)and MA Hong-mei(6 articles).Guang'anmen Hospital of China Academy of Chinese Medical Sciences published the most papers.High-frequency keywords included"modified Danggui Sini decoction""diabetic peripheral neuropathy""Treatise on Cold-Attack""clinical application",etc.Conclusion The research hotspots of Danggui Sini decoction mainly focus on the related fields such as prescription research,clinical application and experimental research.Exploring the mechanism of related pathways based on network pharmacology and other methods is the research trend in this field.