新活素联合地高辛治疗慢性心衰急性加重期的疗效分析

Curative Effect of rhBNP Combined with Digoxin in the Treatment of Acute Exacerbation of Chronic Heart Failure

目的研究新活素联合地高辛治疗慢性心衰(CHF)急性加重期的临床疗效。方法纳入2021年1月-2022年12月定南县第一人民医院收治的60例CHF急性加重期患者为研究对象,利用随机数字表法分为对照组与观察组,各30例。对照组给予地高辛治疗,观察组给予新活素联合地高辛治疗,比较两组治疗效果、心功能指标[左心室射血分数(LVEF)、左室舒张末期容量(LVEDV)、左室收缩末期容量(LVESV)]、24 h尿量、尿素氮(BUN)、不良反应发生率。结果观察组治疗总有效率为93.33%,高于对照组的76.67%(P<0.05);两组治疗后LVEF大于治疗前,LVEDV、LVESV小于治疗前,且观察组LVEF大于对照组,LVEDV、LVESV小于对照组(P<0.05);两组治疗后24 h尿量大于治疗前,BUN小于治疗前,且观察组24 h尿量大于对照组,BUN小于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论新活素联合地高辛治疗CHF急性加重期的疗效肯定,可改善患者心功能,增加尿量,下调BUN水平,安全性高。

Objective To study the clinical efficacy of rhBNP combined with digoxin in the treatment of acute exacerbation of chronic heart failure(CHF).Methods Sixty patients with acute exacerbation of CHF admitted to Dingnan County First People's Hospital from January 2021 to December 2022 were included in the study.They were divided into control group and observation group by random number table method,with 30 patients in each group.The control group was treated with digoxin,and the observation group was treated with rhBNP combined with digoxin.The therapeutic effect,cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV)],24 h urine volume,urea nitrogen(BUN),and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.33%,which was higher than 76.67%in the control group(P<0.05).After treatment,LVEF in the two groups was higher than that before treatment,LVEDV and LVESV were lower than those before treatment,and LVEF in the observation group was higher than that in the control group,LVEDV and LVESV were lower than those in the control group(P<0.05).The 24 h urine volume of the two groups after treatment was greater than that before treatment,BUN was less than that before treatment,and the 24 h urine volume of the observation group was greater than that of the control group,BUN was less than that of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion rhBNP combined with digoxin is effective in the treatment of acute exacerbation of CHF,which can improve cardiac function,increase urine volume,reduce BUN level,and has high safety.