雷贝拉唑联合蓝芩口服液治疗慢性咽炎的效果及对患者临床症状、炎性因子和免疫功能的影响

Effect of Rabeprazole Combined with Lanqin Oral Solution in the Treatment of Chronic Pharyngitis and its Influence on Clinical Symptoms,Inflammatory Factors and Immune Function

目的研究雷贝拉唑联合蓝芩口服液治疗慢性咽炎的效果及对患者临床症状、炎性因子及免疫功能的影响。方法选取2021年6月-2022年6月天津市第三中心医院分院耳鼻喉科就诊的74例慢性咽炎患者,经随机数字表法分为对照组(37例)与观察组(37例)。两组均给予布地奈德雾化吸入治疗,在此基础上,对照组加用蓝芩口服液治疗,观察组则应用雷贝拉唑联合蓝芩口服液治疗,比较两组治疗效果、临床症状、症状缓解时间、炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]、免疫功能[外周血T淋巴细胞亚群(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))]。结果观察组治疗总有效率为94.59%,高于对照组的78.38%(P<0.05);观察组症状评分(咽部干痒、声音嘶哑、异物感、咽部堵塞)低于对照组(P<0.05);观察组症状缓解时间(咽部干痒、声音嘶哑、异物感、咽部堵塞)短于对照组(P<0.05);观察组TNF-α、IL-6水平低于对照组(P<0.05);观察组CD4^(+)、CD4^(+)/CD8^(+)高于对照组(P<0.05)。结论雷贝拉唑联合蓝芩口服液治疗慢性咽炎疗效肯定,可改善患者的临床症状,加速其症状缓解,同时下调体内炎性因子,促进机体免疫功能提升。

Objective To study the effect of rabeprazole combined with Lanqin oral solution in the treatment of chronic pharyngitis and its effect on clinical symptoms,inflammatory factors and immune function.Methods A total of 74 patients with chronic pharyngitis who were admitted to the Department of Otorhinolaryngology,Branch of Tianjin Third Central Hospital from June 2021 to June 2022 were selected and divided into control group(37 patients)and observation group(37 patients)by random number table method.Both groups were treated with budesonide atomization inhalation.On this basis,the control group was treated with Lanqin oral solution,while the observation group was treated with rabeprazole combined with Lanqin oral solution.The therapeutic effect,clinical symptoms,symptom relief time,inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],immune function[peripheral blood T lymphocyte subsets(CD4^(+),CD8^(+),CD4^(+)/CD8^(+))]were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.59%,which was higher than 78.38%in the control group(P<0.05).The symptom scores(throat itching,hoarseness,foreign body sensation,pharyngeal obstruction)in the observation group were lower than those in the control group(P<0.05).The symptom relief time(throat itching,hoarseness,foreign body sensation,pharyngeal obstruction)in the observation group was shorter than that in the control group(P<0.05).The levels of TNF-αand IL-6 in the observation group were lower than those in the control group(P<0.05).CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group(P<0.05).Conclusion Rabeprazole combined with Lanqin oral solution is effective in the treatment of chronic pharyngitis,which can improve the clinical symptoms of patients,accelerate the relief of symptoms,down-regulate inflammatory factors in the body,and promote the improvement of immune function.