van der Linden评分和营养风险筛查2002评分与脊柱转移瘤患者预后的关系研究

Correlations of van der Linden score and nutritional risk screening 2002 score with the prognosis of patients with spinal metastases

目的探讨van der Linden评分和营养风险筛查2002(NRS 2002)评分与脊柱转移瘤患者预后的关系。方法回顾性分析2010年1月—2020年12月宜宾市第一人民医院骨科收治的脊柱转移瘤住院患者127例的临床资料,随访时间截至2022年6月30日。采用Kaplan-Meier法绘制生存曲线,Log-rankχ2检验和Cox回归分析探讨van der Linden评分和NRS 2002评分与患者预后的关系。结果平均随访时间11.7个月,中位生存时间为10个月,随访期内病死率76.38%,6个月和12个月生存率分别为69.29%和27.56%。van der Linden评分0~3分、4~5分和6分的患者生存时间分别为(7.50±2.86)、(15.45±4.49)和(19.00±6.40)个月,12个月生存率分别为3.75%、65.00%和85.71%;NRS 2002评分<3分和≥3分的患者12个月生存率分别为34.21%和17.65%。Cox回归分析显示,van der Linden评分和NRS 2002评分是脊柱转移瘤预后的影响因素。以van der Linden评分为6分的HR(95%CI)为参照,van der Linden评分0~3分和4~5分的HR(95%CI)分别为6.915(2.048~23.363)和1.715(1.068~2.757);以NRS 2002评分<3分的HR(95%CI)为参照,NRS 2002评分≥3分的HR(95%CI)为1.838(1.186~2.850)。结论脊柱转移瘤患者整体预后差,van der Linden评分和NRS 2002评分与患者预后有一定相关性。

Objective To explore the correlations of van der Linden score and nutritional risk screening 2002(NRS 2002)score with the prognosis of patients with spinal metastases.Methods From January 2010 to December 2020,the clinical data of 127 hospitalized patients with spinal metastases admitted to the First Peoples′Hospital of Yibin were retrospectively analyzed,the follow-up was up to June 30,2022.The Kaplan-Meier method was used to draw the survival curve,and Log-rankχ2 test and Cox regression were used to analyze the correlations of van der Linden score and NRS 2002 score with the prognosis of patients with spinal metastases.Results The average follow-up time was 11.7 months,and the median survival time was 10 months.The mortality rate during the followup period was 76.38%,and the 6-month and 12-month survival rates were 69.29%and 27.56%,respectively.The survival time of patients with van der Linden scores of 0 to 3 points,4 to 5 points,and 6 points was(7.50±2.86)months,(15.45±4.49)months,and(19.00±6.40)months,with the 12-month survival rates of 3.75%,65.00%,and 85.71%,respectively.The 12-month survival rates of patients with NRS 2002 scores<3 points and≥3 points were 34.21%and 17.65%,respectively.Cox regression analysis showed that van der Linden score and NRS 2002 score were influencing factors for the prognosis of spinal metastases.Taking HR(95%CI)of van der Linden score at 6 points as the reference,the HR(95%CI)of van der Linden scores at 0 to 3 points and 4 to 5 points were 6.915(2.048 to 23.363)and 1.715(1.068 to 2.757),respectively.The HR(95%CI)of NRS 2002 scores≥3 was 1.838(1.186 to 2.850)taking NRS 2002<3 score as the reference.Conclusion The overall prognosis of patients with spinal metastases is poor.The van der Linden score and NRS 2002 score are related with the prognosis of patients.