非洲被忽视热带病的大规模人群服药现状与挑战

Status and challenges of mass drug administration for neglected tropical diseases in Africa

被忽视的热带病(Neglected tropical diseases,NTDs)是一组与贫困密切相关的慢性感染性疾病,有超过10亿人受其影响,非洲是受影响最严重的地区之一,占全球NTDs疾病负担的近40%。过去十年,大规模人群服药(Mass drug administration,MDA)作为核心策略之一,在加速NTDs消除进程中发挥了巨大作用。近年来,受新冠肺炎疫情影响,非洲部分地区MDA活动中断,NTDs疾病控制面临挑战,严重阻碍非洲可持续发展进程。本文综述了非洲地区需预防性化疗的NTDs流行现状,回顾近三年MDA实施情况,为非洲消除NTDs提供建议。

Neglected Tropical Diseases(NTDs)are a group of chronic infectious diseases strongly associated with poverty,affecting over 1 billion people globally,with Africa being one of the most heavily impacted regions,contributing to nearly 40%of the global disease burden of NTDs.Mass drug administration(MDA)has played a major role as one of the core strategies for eliminating,controlling and eradicating of NTDs in the last decade.However,in recent years,MDA activities have been disrupted due to the impact of COVID-19,posing significant challenges to NTDs control efforts and seriously impeding sustainable development in Africa.This paper assesses the current prevalence of NTDs requiring prophylactic chemotherapy in Africa,reviews the implementation of MDA over the past three years,and provides recommendations for the elimination of NTDs in Africa.