胰腺癌器官特异性肺转移机制的研究进展

Research progress on the mechanism of organ-specific lung metastasis in pancreatic cancer

胰腺癌是一种高度恶性的消化系统肿瘤,由于早期无特异性的临床症状,其早期诊断非常困难,几乎一半的胰腺癌患者在初次确诊时已经发生了远处转移,转移性胰腺癌的生物学特性研究尤为重要。近年来,胰腺癌的器官特异性转移受到了广泛关注,胰腺癌肺转移患者表现出显著的生存优势。与其他部位转移相比,胰腺癌肺转移在基因表达、肿瘤微环境及肿瘤干细胞等多个方面也存在显著差异。本文对胰腺癌器官特异性肺转移机制的研究进展进行综述。

Pancreatic cancer is a highly malignant tumor of the digestive system.Due to the non-specific clinical symptoms in the early stage,its early diagnosis is very difficult.Almost half of the patients with pancreatic cancer have already developed distant metastases at the time of initial diagnosis.In recent years,organ-specific metastasis of pancreatic cancer has received extensive attention.Patients with lung metastasis of pancreatic cancer have shown significant survival benefits.Compared with other metastatic sites,lung metastasis of pancreatic cancer also shows significant differences in gene expression,tumor microenvironment,tumor stem cells and other aspects.This review summarized the research progress on the mechanism of organ-specific lung metastasis in pancreatic cancer.