2006-2022年张家港市60岁及以上居民前列腺癌疾病负担分析

Disease burden of prostate cancer among residents at ages of 60 years and older in Zhangjiagang City from 2006 to 2022

目的了解2006-2022年江苏省张家港市≥60岁居民前列腺癌发病、死亡和疾病负担的变化趋势,为完善前列腺癌防控策略提供依据。方法通过张家港市全民健康信息平台的慢性病监测及管理系统收集2006-2022年张家港市≥60岁居民的前列腺癌发病和死亡资料,计算粗发病率和粗死亡率,采用2010年全国第六次人口普查数据进行标化;参照2019年全球疾病负担前列腺癌数据,计算早死损失寿命年(YLL)、伤残损失健康寿命年(YLD)和伤残调整寿命年(DALY);采用平均年度变化百分比(AAPC)分析前列腺癌发病率、死亡率及负担趋势。结果2006-2022年张家港市≥60岁居民前列腺癌粗发病率为89.85/10万,标化发病率为83.87/10万;粗死亡率为32.31/10万,标化死亡率为25.45/10万;DALY粗率为546.39/10万,标化率为483.50/10万,呈上升趋势(AAPC=5.346%、4.219%、6.648%、3.697%、4.198%和2.200%,均P<0.05)。前列腺癌粗发病率、粗死亡率和DALY粗率随年龄增加呈上升趋势(均P<0.05),2006-2022年60~<65岁、65~<70岁和70~<75岁居民粗发病率呈上升趋势(AAPC=4.888%、8.086%和3.005%,均P<0.05),≥80岁居民粗死亡率和DALY粗率呈上升趋势(AAPC=10.243%和9.693%,均P<0.05)。结论2006-2022年张家港市≥60岁居民前列腺癌发病率和死亡率升高,疾病负担持续增加,其中60~<75岁居民前列腺癌发病率,≥80岁居民前列腺癌死亡率和疾病负担的上升趋势更为显著。

Objective To investigate the trends in incidence,mortality and disease burden of prostate cancer among resi-dents at ages of 60 years and older in Zhangjiagang City,Jiangsu Province from 2006 to 2022,so as to provide in-sights into improvements in the prostate cancer control strategy.Methods The incidence and mortality of prostate can-cer among residents at ages of 60 years and older in Zhangjiagang City from 2006 to 2022 were collected from the Chronic Diseases Monitoring and Management System in the National Health Information Platform of Zhangjiagang City,and the crude incidence and mortality of prostate cancer were calculated and standardized to data from the sixth nation-al population census in China in 2010.Based on the disease burden of prostate cancer captured from the 2019 Global Burden of Disease Study datasets,the years of life lost due to premature death(YLL)and years of life lived with dis-ability(YLD)and disability-adjusted life years(DALY)due to prostate cancer were measured,and trends in incidence,mortality and disease burden of prostate cancer were analyzed using average annual percent change(AAPC).Results The crude incidence,standardized incidence,crude mortality,standardized mortality,crude DALY rate and standardized DALY rate of prostate cancer were 89.85/105,83.87/105,32.31/105,25.45/105,546.39/105 and 483.50/105 among residents at ages of 60 years and older in Zhangjiagang City from 2006 to 2022,which all appeared a tendency towards a rise(AAPC=5.346%,4.219%,6.648%,3.697%,4.198%and 2.200%,all P<0.05).The crude incidence,mortality and DALY rate of prostate cancer all appeared a tendency towards a rise with age(all P<0.05),with a tendency towards a rise seen for the crude incidence of prostate cancer among residents at ages of 60 to 64 years,65 to 69 years and 70 to 74 years(AAPC=4.888%,8.086%and 3.005%,all P<0.05),and a tendency towards a rise for the crude mortality and DALY rate among residents at ages of 80 years and older(AAPC=10.243%and 9.693%,both P<0.05).Conclusion The incidence and mortality of prostate cancer showed a tendency towards a rise among residents at ages of 60 years and older in Zhangjiagang City from 2006 to 2022,and the disease burden due to prostate cancer continued to in-crease,with a more remarkable increasing tendency seen for the incidence of prostate cancer among residents at ages of 60 to 74 years and for the mortality among residents at ages of 80 years and older.