中药治疗缺血性脑卒中质量标志物研究进展

Research Progress on Quality Markers of Ischemic Stroke Treated with Traditional Chinese Medicine

脑卒中是一种具有高死亡率、高致残率、高发病率的大型公共卫生问题。缺血性脑卒中是其中最常见的一种发病类型,中药对脑卒中的治疗具有明显优势,且副作用较小。但中药发挥疗效的关键在于中药质量标志物,因此全面追踪和评价治疗脑卒中的中药仅靠个别指标成分还不够全面,需立足于中药质量标志物。通过查阅相关文献资料,在质量标志物(Q-Marker)的指导下,基于治疗脑卒中的中药化学物质成分传递、植物亲缘学、药物动力学、代谢组学、肠道菌群及网络药理学等方面分析与预测治疗脑卒中的中药质量内涵,推测其有效的质量标志物。

Stroke is a large public health problem with high mortality,disability and morbidity.Ischemic stroke is one of the most common types of disease.Traditional Chinese medicine has obvious advantages in the treatment of stroke,and has less side effects.However,the key to the efficacy of traditional Chinese medicine lies in the quality markers of traditional Chinese medicines.Therefore,the comprehensive tracking and evaluation of traditional Chinese medicines for the treatment of stroke is not comprehensive enough by relying on individual index components,and it needs to be based on the quality markers of traditional Chinese medicines.In this paper,under the guidance of quality markers(Q-Marker)by consulting relevant literature,based on the delivery of chemical components of traditional Chinese medicine in the treatment of stroke,phytogenetics,pharmacokinetics,metabolomics,intestinal flora and network pharmacology etc.to comprehensively analyze and predict the quality connotation of traditional Chinese medicine for the treatment of stroke,and speculate on its effective quality markers,in order to provide a scientific basis for such research.