定量血流分数的临床应用与进展

Clinical application and progress of quantitative flow fraction

近年来,冠状动脉(冠脉)功能学指标在临床应用中愈发受到重视。血流储备分数(FFR)作为评估冠脉功能学狭窄的金标准,其高准确性及临床价值已被大量研究证实。但FFR操作复杂耗时,需要使用部分患者无法耐受的微循环扩张药物,导致其临床应用停滞不前。而定量血流分数(QFR)克服了传统FFR方法的主要不足,同时与FFR具有良好的一致性,在不同的患者亚群之间具有相当的诊断效能,使其在临床上具有广泛的适用性和实用性。本文将对QFR的原理、诊断效能、临床决策、预后风险评估等多个方面进行阐述。

In recent years,there has been a growing emphasis on the clinical application of functional indicators for coronary arteries.Fractional flow reserve(FFR) is the gold standard for evaluating coronary functional stenosis,its high accuracy and clinical value has been confirmed by many studies.However,the FFR operation is complicated and time-consuming,and requiring the use of microcirculation dilating drugs that some patients cannot tolerate,leading to a stagnation in its clinical application.Quantitative flow fraction(QFR) overcomes these major shortcomings of traditional FFR and exhibits excellent consistency with FFR.It demonstrates comparable diagnostic efficacy across different patient subgroups,rendering it widely applicable and practical in clinical settings.This article will be elaborate based on the principles of QFR,diagnostic efficacy,clinical decision-making,prognostic risk assessment and other perspectives.