糖尿病及其并发症与m6A甲基化关系的研究进展

Research advances in the relationship among diabetes,its complications,and m6A methylation

糖尿病作为本世纪的重大医学问题,会对包括肾、心、眼睛、神经和血管在内的主要器官造成损害,最终导致糖尿病并发症,严重威胁个人健康。表观遗传学通过多种机制对糖尿病的发生和发展产生重要影响,促进代谢记忆的产生和维持,最终导致预后不良。大量研究探索了DNA和蛋白质修饰的表观遗传调控与糖尿病的关系,但有关糖尿病的RNA修饰研究甚少。N6-甲基腺嘌呤(N6-methyladenosine,m6A)介导的基因表达调控,对正常生理学和病理生理状态都至关重要。m6A甲基化修饰参与糖尿病及其并发症的发生和发展,使其成为潜在的疾病特异性治疗靶点。深入探讨m6A甲基化修饰的生物学功能在糖尿病及其并发症中的作用,可以为m6A甲基化修饰在糖尿病及其并发症中的未来应用提供治疗参考。

Diabetes,as a major medical problem of this century,causes damage to major organs,including kidneys,heart,eyes,nerves,and blood vessels,eventually leading to diabetic complications,posing a serious threat to individual health.Epigenetics has an important impact on the occurrence and progression of diabetes mellitus through various mechanisms and promotes the generation and maintenance of metabolic memory,thus ultimately leading to a poor prognosis.Substantial studies have explored the relationship between DNA and protein modification in epigenetic regulation and diabetes,but research on RNA modification in diabetes remains limited.N6-methyladenosine(m6A)-mediated regulation of gene expression is essential for both normal physiological and pathophysiological states.Several recent studies have shown that m6A methylation modification is involved in the occurrence and development of diabetes and its complications,making it a potential disease-specific therapeutic target.An in-depth investigation of the biological functions of m6A methylation modification in diabetes and its complications can provide a therapeutic reference for the future application of m6A methylation modification in the treatment of diabetes and its complications.