聚乙二醇融合离断脊髓治疗完全性脊髓损伤的研究进展

Research Progress in the Treatment of Complete Spinal Cord Injury by Polyethylene Glycol Fusion

聚乙二醇(PEG)是由环氧乙烷活性阴离子开环聚合而成的线型聚合物,是一种相对安全和稳定的药物,PEC能封闭脊髓轴突断端膜、融合轴突,重新连接脊髓信号通路,使脊髓断面上下大脑神经信号的传递恢复成为可能,基于这一特点,广西中医药大学附属瑞康医院的任晓平团队对脊髓损伤(spinal cord injury,SCI)这一医学界难题提出了一种新的治疗方法,即利用“锋利的刀”构建的脊髓完全横断模型中脊髓断面处应用PEG,通过行为学观察、弥散张量成像(DTI)、电生理学检查等方法检测和观察疗效。现已成功在小鼠、大鼠、比格犬和食蟹猴动物中完成实验研究,并取得了重要进展。这项创新技术-“脊髓融合术(SCF)”目前正在临床试验中,有望给广大SCI患者带来康复希望。

Objective:Polyethylene glycol(PEG)is a linear polymer formed by ring-opening polymerization of ethylene oxide active anions.It is a relatively safe and stable drug.PEG can seal the spinal cord axon stump membrane and fusion axis.Based on this feature,Ren Xiaoping's team from Ruikang hospital afiliated to Guangxi university of traditional Chinese medicine conducted a study on spinal cord injury(SCI).A new treatment method is proposed for the world problem,that is,the application of PEG to the spinal cord section in the spinal cord complete transection model constructed by"sharp knife",and the detection by behavioral observation,difusion tensor imaging(DTI),electrophysiological examination and other methods.and observe the effect.Experimental studies have been successflly completed in mice,rats,beagle dogs and cynomolgus monkeys,and important progress has been made.This innovative technology,"spinal cord fusion(SCF)",is currently in clinical trials,which is expected to bring hope to the majority of SCI patients.