爬行脂肪中的非免疫细胞成分在克罗恩病发生发展中的作用

Role of non-immune cell components in the creeping fat involved in Crohn′s disease development

克罗恩病(CD)炎性肠段外肥厚增生并包绕肠周超过50%肠系膜脂肪被称为爬行脂肪。目前对爬行脂肪的研究多集中于免疫细胞和易位细菌的作用。而其中大量的非免疫细胞成分, 即脂肪干细胞、脂肪细胞、内皮细胞和成纤维细胞等的作用常被忽视。随着这些细胞参与CD发病的证据不断增多, 对其调节免疫稳态和炎症的机制均有了新的认识。本文重点综述爬行脂肪中非免疫细胞成分作用的最新研究进展, 以完善CD的发病机制和探索CD基于肠系膜治疗的新策略。

The thickened and hypertrophic mesenteric fat that surrounds the inflamed intestine over 50%in Crohn′s disease(CD)is commonly defined as creeping fat.Most previous studies have focused on the mechanism of interaction between immune cells and translocated bacteria in it.However,the massive non-immune cells,including adipose-derived stem cells,adipocytes,endothelial cells and fibroblasts etc.in the mesenteric fat tissue have often been neglected.With the increasing evidence on non-immune cells in the pathogenesis of CD,their involvement in immune homeostasis and regulation of inflammationis gaining new insights.This review highlights the latest research progress on the impact of non-immune cell components in creeping fat,improving the pathogenesis of CD and explores new strategies based on mesenteric therapy.