摘要
急性肾损伤(AKI)是心脏手术后常见且后果严重的并发症之一,与围手术期死亡率增加、重症监护病房停留时间较长和住院时间延长及治疗费用增加密切相关,早期诊断及早期预防AKI可以显著减少这些不良后果。依靠血清肌酐水平和尿量变化来诊断心脏手术相关急性肾损伤(CSA-AKI)的诊断标准由于存在一定的延迟,不能满足早期诊断的临床需要。因此寻找更加精准和特异的CSA-AKI早期生物标志物成为近年来的研究热点。本文就CSA-AKI早期生物标志物的研究进展予以综述。
Acute kidney injury(AKI)is one of the most common and serious complications after cardiac surgery,which is closely related to the increase of perioperative mortality,the prolongation of intensive care unit and hospitalization residence time and the increase of treatment cost.Early diagnosis and early prevention of AKI can significantly reduce these adverse consequences.The diagnostic criteria for diagnosing cardiac surgery-associated acute kidney injury(CSA-AKI)relying on changes in serum creatinine levels and urine output cannot meet the clinical needs of early diagnosis due to certain diagnostic delays.Therefore,the search for early biomarkers of CSA-AKI has become a research hotspot in recent years.This article reviews the early biomarkers of CSA-AKI.
作者
林祥蓉
秦竹韵
宋磊
邢大一
申宇
王欣
岳广新
杨新卫
LIN Xiangrong;QIN Zhuyun;SONG Lei;XING Dayi;SHEN Yu;WANG Xin;YUE Guangxin;YANG Xinwei(Department of Cardiothoracic Surgery,The First Clinical Medical College of Shanxi Medical University,First Hospital of Shanxi Medical University,Taiyuan 030001,China;State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,National Center for Cardiovascular Disease,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China;Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovascular Implant Materials,Animal Experimental Centre,Fuwai Hospital,National Centre for Cardiovascular Disease,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China)
出处
《中国分子心脏病学杂志》
CAS
2023年第5期5699-5706,共8页
Molecular Cardiology of China
基金
北京市科技计划课题(Z201100005520004)
中国医学科学院阜外医院国家心血管疾病临床医学研究中心自主课题(NCRC2020010)。
