自组装多肽用于药物递送的研究进展

Progress in self⁃assembling peptides for drug delivery

近年来,自组装多肽(SAP)因具有良好的生物相容性、灵敏的响应性及特定的生物功能而备受关注。SAP在特定情况下能形成规则有序的纳米结构,表现出不同于单分子的优势和特性,已广泛应用于细胞培养、组织工程和药物递送等领域。该文主要对多肽自组装形成的纳米类型及其在药物递送方面的应用进行综述,包括化学小分子及核酸、多肽、蛋白质等生物大分子,总结了SAP作为药物递送载体所面临的挑战,并展望其发展前景。

In recent years,self⁃assembling peptides(SAPs)have attracted attention due to their good biocompatibility,sensitive responsiveness,and specific biological functions.SAPs are capable of forming regular and ordered structures under specific conditions,and exhibit advantages and properties different from those of single molecules.SAPs have been widely used in cell culture,tissue engineering and drug delivery.This paper reviews the formation of nano types by SAPs and their applications in drug delivery,including chemical small molecule drug delivery and biomacro⁃molecule drug delivery such as nucleic acids,peptides and proteins.Finally,the challenges faced by SAPs as drug delivery vehicles are summarized and their prospect of development is described.