压疮感染患者的病原菌分布及胰蛋白酶疗效观察

Distribution of pathogenic bacteria in patients with pressure ulcer infection and therapeutic effect of trypsin

目的探究压疮感染患者的病原菌分布及胰蛋白酶的疗效。方法回顾性分析保定市第二医院2020—2022年120例压疮感染患者的临床资料。其中,采用常规治疗60例(对照组),常规治疗联合胰蛋白酶治疗60例(观察组)。记录病原菌分布情况,比较两组局部病原菌转阴率、疗效和换药次数。结果120例患者共分离出71株病原菌,其中革兰阳性菌39株(54.93%),革兰阴性菌28株(39.44%),真菌4株(5.63%)。观察组总有效率和局部病原菌转阴率明显高于对照组[96.67%(58/60)比81.67%(49/60)和75.00%(45/60)比50.00%(30/60)],换药次数明显少于对照组[(12.48±2.10)次比(27.34±3.21)次],差异有统计学意义(P<0.01)。结论压疮感染患者的病原菌主要为革兰阳性菌,结合胰蛋白酶治疗可明显提高疗效和局部病原菌转阴率,减少换药次数。

Objective To explore the distribution of pathogenic bacteria in patients with pressure ulcer infection,and observe the curative effect of trypsin.Methods The clinical data of 120 patients with pressure ulcer infection in the Second Hospital of Baoding City from 2020 to 2022 were retrospectively analyzed.Among them,60 cases were treated with conventional treatment(control group),and 60 cases were treated with conventional treatment combined with trypsin(observation group).The distribution of pathogenic bacteria was recorded,and local negative conversion rate,curative effect and frequency of dressing change were compared between two groups.Results A total of 71 strains of pathogenic bacteria were isolated from 120 patients,including 39 Gram-positive bacteria(54.93%),28 Gram-negative bacteria(39.44%)and 4 fungi(5.63%).The total effective rate and local negative conversion rate of pathogens in observation group were significantly higher than those in control group:96.67%(58/60)vs.81.67%(49/60)and 75.00%(45/60)vs.50.00%(30/60),the number of dressing changes was significantly lower than that in control group:(12.48±2.10)times vs.(27.34±3.21)times,and there were statistical differences(P<0.01).Conclusions The main pathogenic bacteria in patients with pressure ulcer infection are Gram-positive bacteria.Combined with trypsin treatment can significantly improve the curative effect and the local negative conversion rate,and reduce the number of dressing changes.