TyG指数、Ca^(2+)、CRP对急性胰腺炎病情严重程度的预测价值研究

The predictive value of TyG index,Ca^(2+),CRP on the severity of Acute pancreatitis

目的探讨甘油三酯葡萄糖指数(TyG指数)、血清钙离子(Ca^(2+))、C反应蛋白(CRP)及三者联合时对急性胰腺炎(AP)严重程度预测能力的研究。方法将2020年5月到2023年5月在本院收治的AP患者作为研究对象,通过对其临床资料进行收集,将患者按照病情严重程度分成两组,分别是75例重症急性胰腺炎(SAP)组和230例非重症急性胰腺炎(非SAP)组,比较两组病人的基本临床特征;应用多因素二元Logistic回归分析,探讨SAP的独立危险因素;利用受试者工作特征曲线(ROC曲线)比较TyG指数、Ca^(2+)、CRP及三者联合时对SAP的预测价值。结果SAP、非SAP两组患者的性别年龄差异无明显统计学意义(P>0.05),但在住院天数、ICU入院人数等上有统计学意义(P<0.05),SAP组的TyG指数、CRP浓度相比于非SAP组明显升高,与非SAP组患者相比,SAP组患者血浆中钙含量显著下降(P<0.05);多元Logistic回归分析表明,这三个因子是预测SAP发生的独立因素,有统计学意义(P<0.05);TyG指数、Ca^(2+)、CRP、三者联合时ROC曲线下面积结果分别如下:0.7130.8330.919、0.972。结论SAP患者人院24小时内的TyG指数、Ca^(2+)、CRP可以在一定程度上反映AP的病情严重程度;TyG指数、Ca^(2+)CRP三个指标为预测AP病情严重程度的独立因素;TyG指数+Ca^(2+)+CRP三者联合对AP病情严重程度的预测价值高于单独检测。

Objective To investigate the predictive ability of Triglyceride glucose index(TyG),Serum caleium(Ca^(2+)),Creactive protein(CRP),and their combination on the severity of Acute pancreatitis(AP).Method AP patients admitted to our hospital from May 2020 to May 2023 were selected as the research subjects.Clinical data were collected and divided into two groups according to the severity of the condition,namely 75 severe acute pancreatitis(SAP)patients and 230 non severe acute pancreatitis(non SAP)patients.The basic clinical characteristics of the two groups of patients were compared;Using multivariate binary logistic regression analysis to explore independent risk factors for SAP;Compare the predictive value of TyG index,Ca^(2+),CRP and their combination on SAP by using the subjects working characteristic curve(Receiver operating characteristic).Result There was no significant difference in gender and age between the SAP and non SAP groups(P>0.05),but there was statistical significance in terms of length of stay and number of ICU admissions(P<0.05).The TyC index and CRP concentration in the SAP group were significantly higher than those in the non SAP group,while the plasma calcium content in the SAP group was significantly lower than that in the non SAP group(P<0.05);Multiple logistic regression analysis showed that these three factors were independent factors in predicting the occur-rence of SAP,with statistical significance(P<0.05);The area under the Receiver operating characteristic of TyG index,Ca^(2+),CRP and their combination are as follows:0.713,0.833,0.919,0.972.Conclusion The TyG index,Ca^(2+),and CRP of SAP patients within 24 hours of admission can reflect the severity of AP to a certain extent;The TyG index,Ca^(2+),and CRP are independent factors for predicting the severity of AP disease;The combination of TyG index,Ca^(2+),and CRP has a higher predictive value for the severity of AP compared to individual tests.