《肺纤维化合并肺气肿综合征ATS/ERS/JRS/ALAT研究共识》解读(二):定义、综合管理及未来研究重点

Interpretation of the"Syndrome of Combined Pulmonary Fibrosis and Emphysema:An Official ATS/ERS/JRS/ALAT Research Statement":Definition,comprehensive management,and future research priorities

以往的研究将患者肺部同时存在肺气肿与肺纤维化称为"肺纤维化合并肺气肿(CPFE)",尽管已有多项关于CPFE的研究,但人们对其定义和管理的了解仍较少。2022年美国胸科学会/欧洲呼吸学会/日本呼吸病学会/拉丁美洲胸科联盟发表的研究共识阐述了CPFE的定义、特征、病理生理机制、综合管理和研究重点等,并建议将CPFE明确为一种综合征,提出了CPFE的研究定义和分类标准,同时建议CPFE的研究应包括对影像学和病理学的全面描述。本文就该研究共识中关于CPFE综合征的定义、患者的综合管理及未来研究重点的部分进行解读。

Coexistence of emphysema and pulmonary fibrosis used to be termed as combined pulmonary fibrosis and emphysema(CPFE).Although there have been many studies on CPFE,its definition and clinical management have been rarely analyzed.In 2022,the"Syndrome of Combined Pulmonary Fibrosis and Emphysema:An Official American Thoracic Society(ATS)/European Respiratory Society(ERS)/Japanese Respiratory Society(JRS)/Asociacion Latinoamericana de Torax(ALAT)Research Statement"proposes the definition,characteristics,pathophysiological mechanisms,comprehensive management and research priorities of CPFE.CPFE is also recommended as a syndrome.This statement proposes the research definition and classification criteria of CPFE,and also recommends the thorough description of radiological and pathological patterns in the research on CPFE.This article interprets the statement on the definition of CPFE as a syndrome,comprehensive management of patients,and future research priorities.