分枝杆菌T7SS(ESX)分泌系统功能研究进展

Progress on the function of Mycobacterium T7SS(ESX)secretion system

分枝杆菌感染宿主后能够通过分泌至胞外的效应蛋白去影响宿主的免疫功能,其中ESX(或Ⅶ型)系统在效应蛋白分泌方面发挥了重要作用。ESX分泌系统是分枝杆菌和许多放线菌中的蛋白质输出系统,但目前ESX系统如何将底物运输穿过外膜的分子机制以及调控机制尚不清楚。本文对ESX系统的组成、功能、分类以及将底物运输至周质空间的相关研究进展展开了综述,并探讨了ESX系统在抗生素耐药、持留及与宿主-噬菌体相互作用中的功能,以及作为新药物靶标的潜力,以期为结核病新药物和疫苗抗原的发现提供新的见解。

Mycobacterium infection can affect the host’s immune function by secreting extracellular effector proteins.ESX(or type VII)system plays an important role in the secretion of effector proteins.ESX system is the protein export system in mycobacteria and many actinomycetes.However,how ESX system secretes and underlying mechanism of action remain unclear.In this review,we introduce the components,function,classification of ESX system and the process of substrates transfer to the peripheral space via this system,and discuss the roles of ESX system in antibiotics resistance,persistence,host-phage interaction,new drug targets.We hope to provide insights into the discovery of new drugs and vaccine antigens for tuberculosis.