肿瘤相关巨噬细胞在肺癌侵袭及治疗中的研究进展

Research advances of tumor-associated macrophages in lung cancer invasion and treatment

肺癌是一种高发病率和死亡率的癌症,而肺癌的侵袭性是导致肺癌患者复发和最终死亡的主要因素之一。肿瘤相关巨噬细胞(tumor-associated macrophages,TAMs)通过分泌细胞因子、生长因子、炎症底物和蛋白水解酶等在肿瘤的启动、生长、侵袭和转移中起重要作用。本文就TAMs的来源、分泌促进肺癌侵袭性的各种物质及其在肺癌治疗中的临床价值进行综述。本文创新地将TAMs分泌的不同物质分别分析,探究其作为新型治疗靶点的可能,尤其详述了TAMs作为新型药物载体的前景,为新型靶向药物的开发和药物运载体的选择提供了新的思路。

Lung cancer has a high morbidity and mortality,and invasion is one of the major factors that cause recurrence and death in lung cancer patients.Tumor-associated macrophages(TAMs)are cells that have the potential to secrete cytokines,growth hormones,inflammatory substrates,and protein hydrolases,which are associated with the growth,invasion and metastasis of tumors.In this article,we will explore the various chemicals that are manufactured to promote the invasion of lung cancer,as well as the numerous clinical therapeutic features that TAMs possess in the treatment of lung cancer.In addition,we look at the possibility that TAMs might be beneficial in the treatment of lung cancer.We have an innovative investigation of the huge variety of complex substances generated by TAMs,with the goal of determining whether or not the molecules under investigation have the potential to serve as new therapeutic targets.Throughout the whole of the presentation,a significant focus is placed on doing in-depth research to ascertain whether TAMs have the capability to reinforce as viable carriers for unique and creative medications.This not only provides novel concepts for the creation of new targeted therapies but also leads to the development of brand-new,cutting-edge methods for the manufacture of individualized medicines and drug carriers.