肝移植术后人类疱疹病毒6B型脑炎1例及文献复习

A case of human herpesvirus 6B encephalitis after liver transplantation and literature review

人类疱疹病毒6型(HHV-6)是一种普遍存在的病毒,肝移植后HHV-6发病率为22%~54%,可表现为发热、肝炎、肺炎、脑炎和骨髓抑制,预后不良;HHV-6(+)受者死亡率为29%,明显高于HHV-6(−)受者(6%)。由于多数为无症状感染,目前临床上并不常规进行HHV-6监测,使得临床医师常常忽略HHV-6的诊断,最终延误诊治。回顾性分析了1例肝移植术后人类疱疹病毒6B型脑炎病例,同时复习了该病的相关文献资料,以提高对该病的认识。

Human herpesvirus-6(HHV-6)is a ubiquitous virus.The incidence of HHV-6 after liver transplantation is estimated to be 22%−54%;it may present with fever,hepatitis,pneumonia,encephalitis,and myelosuppression and has a poor prognosis.HHV-6(+)recipients had a mortality rate of 29%,significantly higher than that of HHV-6(−)recipients(6%).Since most infections are asymptomatic,HHV-6 monitoring is not routinely performed in clinical practice,which means clinicians often ignore the diagnosis of HHV-6 and eventually delay diagnosis and treatment.In this paper,a case of human herpesvirus 6B encephalitis after liver transplantation was retrospectively analyzed,and the literature related to this disease was reviewed to improve the understanding of this disease.