儿童慢性无菌性骨髓炎诊疗进展

Research advances of chronic nonbacterial osteomyelitis in children

慢性无菌性骨髓炎又称为慢性复发性多灶性骨髓炎,是一种影响儿童和青少年的炎症性骨病,发病率约为百万分之一,属于罕见病的范畴。儿童慢性无菌性骨髓炎的临床表现主要为夜间复发性炎症性骨痛,疼痛具有反复发作与间断缓解的特征。目前诊断主要依靠排除诊断,除外如感染性骨髓炎和骨肿瘤等疾病。本研究简要介绍了儿童慢性无菌性骨髓炎的发病机制,重点综述了疾病诊断、治疗的研究进展,以期为临床提供参考。

Also known as chronic recurrent multifocal osteomyelitis(CRMO),chronic nonbacterial osteomyelitis(CNO)is a rare inflammatory bone disease with an incidence of one in a million in both children and adolescents.One major clinical manifestation of CNO is nocturnal recurrent inflammatory bone pain with frequent recurrence and intermittent remission.Currently a definite diagnosis is dependent upon excluding such diseases as infectious osteomyelitis and bone tumors.This review offered a systemic discussion of pathogenesis,diagnosis and treatment of CNO.