瘦型非酒精性脂肪性肝病的研究进展

Research advances in lean nonalcoholic fatty liver disease

非酒精性脂肪性肝病(NAFLD)是目前全球慢性肝病的主要原因,可进展为肝炎、肝纤维化、肝硬化甚至肝细胞癌,虽然肥胖在NAFLD发生中起着关键作用,但越来越多的研究证实NAFLD在瘦型个体中依然存在,且瘦型NAFLD的死亡风险增加、疾病进展加速。因此,瘦型NAFLD也值得仔细评估和随访,但目前有关瘦型NAFLD的病理生理机制仍知之甚少,本文就瘦型NAFLD的病因、诊断、治疗及预后作一综述。

Nonalcoholic fatty liver disease(NAFLD)is currently the main cause of chronic liver disease worldwide,and it can progress to hepatitis,liver fibrosis,liver cirrhosis,and even hepatocellular carcinoma.Although obesity plays a key role in the development of NAFLD,more and more studies have confirmed that NAFLD still exists in lean individuals,and lean NAFLD is associated with an increased risk of death and accelerated disease progression.Therefore,lean NAFLD also deserves careful evaluation and follow-up;however,we still know little about the pathophysiological mechanism of lean NAFLD.This article reviews the etiology,diagnosis,treatment,and prognosis of lean NAFLD.