基于中西医临床病证特点的胆汁淤积性肝病动物模型评价

Evaluation of cholestatic liver disease animal model based on clinical syndrome characteristics of integrated traditional Chinese and Western medicine

胆汁淤积性肝病是一种临床常见的肝胆系统疾病,其病因及发病机制复杂,建立合适的胆汁淤积性肝病动物模型是深入研究其发病机制及防治的基础。本研究通过总结归纳现有的胆汁淤积性肝病动物模型造模方法、作用机制及模型特点,基于胆汁淤积性肝病的现代医学临床诊断标准、中医证候特点,分析其与中西医临床病证特点的吻合度,为建立规范的更符合中西医临床实际的胆汁淤积性肝病动物模型及评价方法提供参考。

Cholestatic liver disease is a common disease of the hepatobiliary system.Its etiology and pathogenesis are complex.The establishment of an appropriate animal model of cholestatic liver disease is the basis for further study of its pathogenesis and prevention.This study summarized the existing modeling methods,mechanisms,and characteristics of this model,and analyzed its alignment with the clinical disease and syndrome characteristics of integrated traditional Chinese and Western medicine based on the modern clinical diagnostic criteria and traditional Chinese medicine syndrome characteristics of cholestatic liver disease,so as to provide a reference for establishing standard animal models and evaluation methods for cholestatic liver disease that accord better with the clinical practice of integrated traditional Chinese and Western medicine.